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  1. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    I did find that the lead author, Wenjing Song, has done at least two mendelian randomization studies before. For Daytime napping and the incidence of Parkinson’s disease: a prospective cohort study with Mendelian randomization, I looked at the SNPs in the paper, and compared them to the SNPs in...
  2. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    Of the 42 SNPs that match those for BMI in Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19, the effect allele and the alternative/other allele listed are exactly the same in both papers for all SNPs.
  3. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    Of the 15 from Zhu that weren't also associated with BMI in the Li paper, I found that at least 13 of them have been associated with BMI in other papers: One of the last two is listed in a table for "obesity" but might mean BMI. The other one I couldn't find an association with BMI through a...
  4. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    Looking at Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19, Li et al. In "Supplementary Table 7. The Association of IVs With Exposure and Severe COVID-19" it lists a lot of SNPs. Interestingly, the first five listed...
  5. forestglip

    Relationship between major depressive disorder and [ME/CFS]: a two-sample mendelian randomization study analysis, 2025, Zhu et al

    Also checked and none of the SNPs match with Supplementary table 1. I also checked Supplementary Table 2 from Howard et al just in case since it lists SNPs, but none of those match Zhu et al's 57 SNPs either. I checked the first few SNPs shown in figure 2 A and D from Zhu just in case those were...
  6. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    In the interests of trying to improve the forum, sure, I'm talking about Amy Proal. https://www.s4me.info/threads/hypothesis-piece-by-amy-proal-a-microbiologist-with-me-cfs.134/ I don't know much about the Marshall Protocol. It might be completely wrong. But I think there are a million ways to...
  7. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    I don't know if it's worth naming this person, but at least one researcher clearly reacted badly because of being the lone person defending themself against a whole group of people basically calling them stupid, some implied and in some cases pretty much explicitly. I don't blame them for...
  8. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    That seems like it might be a good idea actually. I imagine at least some will want to take a look out of curiosity, and hopefully a few will want to clear up any misconceptions or clarify anything important that we're missing.
  9. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    I glossed over this before. What do you mean "start Covid-19"?
  10. forestglip

    Where can patients argue with clinicians and scientists about bad science in ME/CFS?

    I've thought the same. I have pretty bad social anxiety disorder, another condition that very often has no effective treatment, and there are a couple big forums for that, but no one is posting about the ongoing research, just sharing experiences of symptoms and of trying existing treatments. I...
  11. forestglip

    News from the Institute of Neuroimmune Medicine (INIM), NOVA, Nancy Klimas

    Wow that conquercfs thing is expensive. The standard course is £1,750 and the ultimate course is £1,999. (I think you can also pay a couple hundred a month instead. Edit: and there is a cheaper "emergency reset" course for £39/month.) The ultimate course includes three one-on-one calls with the...
  12. forestglip

    PolyBio Fall 2024 Symposium

    2:50:17 Petter Brodin–Sex Hormone Regulation of the Immune System Main takeaways: Peter Brodin's lab is interested in genetics of long COVID, particularly genes involved in antiviral immunity. They hope to report results of a whole genome sequencing study of 110 people with severe long COVID...
  13. forestglip

    Preprint Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects,

    Investigating the Severity and Timeline of PASC Symptoms: Focus on Physiological and Cognitive Effects Rohan Melwani, Keerthana Noru, Sanya Kondapalli, Ameya Ravi, Saanvi Shah, Shreeya Setty, Shashank Sastry, Sahar Jahanikia [Preprint] Abstract The SARS-CoV-2 virus, responsible for the...
  14. forestglip

    Preprint Effect of Immunoadsorption on clinical presentation and immune alterations in COVID-19-associated ME/CFS, 2024, Anft

    Well, spike protein too. Do you know why that would happen? Edit: From discussion about spike protein findings: So likely just: "However, since high titers of SARS-CoV-2 spike protein specific antibodies were detected in all patients, it is likely that these antibodies bound to soluble spike...
  15. forestglip

    What high-quality resources should S4ME produce for PwME, clinicians, researchers etc.?

    Also maybe some information about using supplements. I often see people on social media posting that they take like 30 supplements. Apart from reiterating that most supplements have no evidence behind them, maybe there could be general info about placebo effect, confounders, and that...
  16. forestglip

    What high-quality resources should S4ME produce for PwME, clinicians, researchers etc.?

    I've seen several places suggest that PEM can be immediate in some people. CDC might have wanted to be inclusive just in case, so that someone whose PEM starts immediately isn't discouraged seeing this saying PEM must be delayed. Edit: From another thread:
  17. forestglip

    Preprint Effect of Immunoadsorption on clinical presentation and immune alterations in COVID-19-associated ME/CFS, 2024, Anft

    Even without a control group, we do see that these may be real effects of the intervention, since they rebounded afterwards: I don't know if any of that is actually relevant, though. Why would IgG removal decrease spike protein in the blood, and only temporarily? And though self-reported...
  18. forestglip

    Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation, 2023, Salvucci et al

    Not placebo controlled. They looked at records of patients who had and had not taken antihistamines.
  19. forestglip

    Scent of COVID-19: [WGS] Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction, 2025, Spedicati et al

    Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction Beatrice Spedicati, Alessandro Pecori, Maria Pina Concas, Aurora Santin, Romina Ruberto, Giuseppe Giovanni Nardone, Andrea D’Alessandro, Giancarlo Tirelli...
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