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Novel Oro-Nasal Drainage for Long COVID: Proposed Mechanisms – Case Report Claudia Lorenz, Roland Frankenberger [Preprint] Abstract Long COVID, potentially emerging post COVID-19 infection, involves extreme health challenges. Based on the current literature in the field, we propose a novel...

It says that in the text, but Table 2 shows higher values for controls for both these proteins. Table 2 also doesn't match the scatter plots in Figure 2, at least for C4. The table says mean of 511.8 for controls but the mean line in the plot is below 500. Table S2 in the supplementary file uses...

DePaul Symptom Questionnaire-PEM Open ended responses

The Beentjes paper found several other complement proteins upregulated as well, including complement factor B (CFB) and complement component 2 (C2), whose genes were also associated with ME/CFS here. Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity...

They found this correlation too, though sex may play a role: Tim Henrich also discussed this finding at the PolyBio symposium.

A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis, 2015, Hisahara et al Adult‐onset very‐long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD), 2020, Fatehi et al Diagnostic assessment and long-term...

Oh yeah, there seem to be various presentations of the disease. Maybe some look like ME/CFS, some don't. From Wikipedia: Diagnosis Prognosis

Since ME/CFS is diagnosed based on symptoms, I don't think this makes sense. If they fit the criteria, then by definition they had it. There might be a thousand causes of ME/CFS, and this is just one.

There's an interesting Reddit post of someone with ME/CFS who eventually found out they have this. After some dietary changes, they've been in remission for 14 months. Link

It feels like a reasonable line of inquiry in an investigation, especially for someone unfamiliar with this condition. Get her to explain exactly why they're talking. Maybe he understands and is just seeing if she might slip up in her explanation that might indicate it's more than what she says...

This part is interesting. I wonder why ME/CFS but not long COVID. Maybe specific to ME/CFS and some in the LC group don't have it? But at least some should have it, and their group level isn't higher at all. Develops over time? I can't find past ME/CFS studies that measured latency of pupil...

I haven't seen this show other than the clip in the last post I just watched. That doesn't seem that bad? Might even say quite impressive for mainstream TV. That he didn't say "Kea says she got ME." already had me kind of astounded. No she definitely got it, according to this guy. Another...

2:40:22 Michael VanElzakker–Understanding Long COVID & ME/CFS brain fog, from cells to circuits Main takeaways: Michael VanElzakker's lab is studying both pre-COVID ME/CFS and long COVID, analyzing participants with MRI, PET, saliva, blood, pupillometry, and sleep testing. In both groups, they...

I assume they mean the CDC criteria, which doesn't require PEM.

This study found some variants in a gene that codes for complement factor H (CFH) which were more common in ME/CFS. This molecule was found to be higher in ME/CFS in this study: Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting...

2015 study Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome Mangalathu S. Rajeevan, Irina Dimulescu, Janna Murray 1, Virginia R. Falkenberg, Elizabeth R. Unger Abstract Recent evidence suggests immune and inflammatory alterations are...

Something else he mentioned in the video that might be interesting: "We just got a paper accepted in Molecular Psychiatry, where a few patients with OCD were treated with Rituximab, and actually, it worked." Thread: Three cases with chronic obsessive compulsive disorder report gains in...

Three cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment Maike Gallwitz, Isa Lindqvist, Jan Mulder, Annica J Rasmusson, Anders Larsson, Evelina Husén, Jesper Borin, Peter J van der Spek, Nour Sabbagh, Anna Widgren, Jonas...

I'd like to see if the association holds if they split it into further than two areas, stratified by exposure level. Also, it'd be interesting to do this with all diseases there is data for in the same two areas and see if the diseases most and least correlated to pesticide exposure are...

They divided Andalusia into two areas based on pesticide use. Case/control criteria No differences in ages. After adjusting for age and sex, they found an odds ratio of 1.64 (1.41-1.89) for having Alzheimer's in the high pesticide areas. Trend of prevalence over time in the two areas...