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The deep phenotyping study has the stool metabolomics statistics in Supplementary File 21. These are sorted by significance. Tyrosine, phenylacetate, and threonine are the other ones they found were significant. (All increased according to the spreadsheet above.) Edit: Unclear if they did...

So low hypoxanthine in the stool has been seen in many quite different health conditions (acute COVID, TB, ADHD, IBS, ankylosing spondylitis, RA). One more if you include ME/CFS. So maybe it is a marker of poor health in general. The plot of hypoxanthine in the two groups of this study above...

Since low fecal hypoxanthine was flagged above, I did a search. Plots of fecal hypoxanthine from the NIH study: Plots of hypoxanthine vs other metabolites mentioned in other studies below as lower. Propionate, uracil, and butyrate look like they might be positively correlated with...

Okay, hopefully I'm done. Here's spreadsheet_final_v2(1)_20. (relevant comic) I split the data into two datasets. Details of how I split are in the Notes tab. I tested correlations for each split and the full dataset. The correlations for the full dataset are the first tab, and the others are...

Interview with Christian Puta who heads “'BioSig-PEM' research group, where six universities are researching the biological background of PEM." He was also senior author of this paper: Towards an understanding of physical activity-induced [PEM]: Insights into microvascular alterations &...

Prevalence of post-acute sequelae of SARS-CoV-2 infection in people living with HIV: a systematic review with meta-analysis Dimitra V. Pouliopoulou, Nicole Billias, Joy C. MacDermid, Erin Miller, Kelly K. O'Brien, Kieran L. Quinn Background Given the chronic immune activation and inflammatory...

For the vaccine as treatment for LC discussion, new study didn't find much difference in numbers who improved or worsened after vaccination: Post-COVID-19 Vaccination and Long COVID: Insights from Patient-Reported Data, 2024, Quach et al But maybe some predictors for improvement:

Post-COVID-19 Vaccination and Long COVID: Insights from Patient-Reported Data Tom C. Quach, Mitchell G. Miglis, Lu Tian, Hector Bonilla, Phillip C. Yang, Lauren Grossman, Amogha Paleru, Vincent Xin, Anushri Tiwari, Robert W. Shafer, Linda N. Geng Introduction: COVID-19 vaccinations reduce the...

Pathophysiology and Management of Postural Orthostatic Tachycardia Syndrome (POTS): A Literature Review Mohamad Ghazal, Abdul Rahman Akkawi, Andrew Fancher, Emmanuel Oundo, Hammad Tanzeem, Laiba Sajjad, Alexandros Briasoulis Abstract Postural Orthostatic Tachycardia Syndrome (POTS) is a form...

Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study Mauro Mantovani, Paolo Bellavite, Serafino Fazio, Giuseppe Di Fede, Marco Tomasi, Daniele Belli, Elisabetta Zanolin Background/Objectives...

I thought including half the healthy controls was a decent enough idea so I went ahead and did that. Everything the same, except half the controls are tied at a PEM score of zero and the other half are excluded for later validation. Browser link First impressions: Now all the top correlations...

Looking at metrics between groups, it's definitely not that straightforward. While those with worse PEM tend to have lower ATP production at baseline, healthy people's ATP production seems to be lower than ME/CFS. I quickly looked at the rest of the comparisons. ATP production is either the...

I decided to just rerun it only based on the PEM score. I want the score to match ME/CFS as well as possible, and I can't be sure the SF-36 is doing that. I added the new correlations as the second tab in the spreadsheet above. One thing I've noticed so far is that pretty much everything from...

From that list, it looks like basically one account posted and around 20 others retweeted it from them. The original account is Physio Meets Science @PhysioMeScience https://www.physiomeetsscience.net/ Might be worth telling them and anyone else who posts it what the deal is to see if they'll...

The PEM - SF-36 severity metric seems to correlate to physical fatigue from the MFI-20: Not as much for mental fatigue: Again weirdly one of the wrist movement counts after CPET was one of the most correlated, with more severe PEM meaning higher wrist movements. This time 27-43 hours...

Hopefully this is the final product. I used the PEM - SF-36 metric as described in the last post, as well as in the Notes tab of the spreadsheet below. I used Kendall's Tau test for correlations because I read that it is more robust to tied values (two participants having the same severity or...

Thanks, just did. For anyone else that wants, here's the link: https://www.cochrane.org/complaints/form

If I go to pubmed and search "exercise cfs review" sorted by most recent it's the first result and says 2024. It's 5th if sorting by best match. Clicking through to the details with the abstract, which might be the extent of what a lot of people do, gives no indication it is a 2019 paper or...

That date change is crazy. I don't have it in me to do a lot, but I wrote this simple message. I'm not sure who to send it to though. "I am writing to express my disappointment in Cochrane's action to update the date of the Lurun 2019 review to December 2024 even though no new research was...

Just posting some interesting stuff I'm learning. Over here I'm working on testing correlations between ME/CFS severity and every lab test they did to see what's most correlated: The severity metric I'm planning to use has a tie, so I was curious if the correlation function I was planning to...