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It seems that Primary Pain arrives on the map with ICD-11. The blurb says. Chronic primary pain is a novel concept originating in the insight that diseases or long-term conditions associated with chronic pain should be acknowledged in their own right, even if a clear understanding of the...

Indeed. Pretending to be a doctor rather than pretending to be a patient. I have not actually heard of 'Primary Pain' before. The next in a long line of weaselisms?

The Guardian have lapped it up. https://www.theguardian.com/society/2020/aug/03/painkillers-such-as-aspirin-do-more-harm-than-good-for-chronic-pain

The whole thing lacks the necessary rigour. It seems that if 'evidence' is generally a bit positive they go with it, regardless of quality or likely bias. I think it seriously inappropriate that guidelines like this should recommend to someone, presumably a generalist prescriber such as a GP...

It seems to be a conspiracy theory site with a major interest in anti-vax and also Nazi experimentation during the holocaust. (Not that the latter would be a conspiracy theory but it indicates a political agenda that probably has no relevance to current reality.) I don't think it is a site...

I would advise against taking that piece too seriously. It looks like a crackpot conspiracy theorist site - as much disinformation as Mr Trump saying hydroxychloroquine was a cure. There is no reason why doses in a trial like this should be the standard daily dose for chronic usage. The author...

I don't know what information is available but my general thought is that the more localised the infection is, as seems to be in Melbourne, the stronger the argument for every restriction you can think of. Governments do not seem to understand that as cases get fewer and more local the argument...

I think that must be right. Turnaround is easy at any stage, never too late - but lockdown has to be maximum. Soft lockdown is a disaster because it produces exactly the opposite effect to that intended.

I pity the adolescents subjected to this approach. As I have indicated elsewhere, I can see no reason why you need to exercise specifically after successful outcome from a severe illness. With a successful outcome you should return to normal fitness when ready. A few people may not, but we have...

Perhaps tension should be contradiction? I find this sort of study useful in that it reveals the true colours of people like Mark Edwards and Jonathan Stone. Anyone genuinely wanting to make evidence-based process in a filed does not sign up to this sort of thing. You could say that...

Many thanks for your very helpful feedback. Apologies if it seems as though we are proposing graded exercise for all; we mean to suggest a suite of interventions that will need to be individually tailored, rather than a blanket approach to all. Will clarify in published version. So how do they...

Simon and Chris Ponting refer to data by Canela-Xandri on BioRxiv. I could not track that down but Simon McGrath should know. I thought there was some recent information from a big epidemiological study in California that happened to check for CFS linkage. Again, Simon would know.

I have only had a quick look at the paper but it seems only to give us IgG and antibody levels for 9 days. This is completely meaningless from my perspective since to be any use one would want antibodies to go down for months at least. (The paper is published in something I have never heard of...

Plasma is the only relevant compartment for antibodies so it is the same as for rituximab. They are not affecting B cells but the relevance of affecting B cells is only through the knock on effect on plasma antibodies in both situations.

The point is that they might be. Resistance to infection is complicated and some people manage on low IgG levels but an 80-90% reduction puts someone into seriously risky territory.

Malmquist's Researchgate entry is interesting. He published in international journals from 1959 to 1987. Since then he has only published in Swedish and mostly opinion pieces. His earlier work was in endocrinology or metabolism. The dates suggest that he is about 85-90 years old? If he was...

An 80-90% decline in total IgG sounds seriously bad news to me. We used to worry if there was a 50% reduction with rituximab. Unless there is some good reason why this is considered acceptable, perhaps in the short term, I would not recommend continuing to study this protocol.

Nothing to see here, again, it seems. At least it is clear that SW has been involved - perhaps as one of those whose names were not available to us.

Well, I may have been overoptimistic saying that the UK government would fall in line with sensible policy by July but this from the Guardian (https://www.theguardian.com/uk-news/2020/jul/29/uk-health-leaders-call-for-government-to-seek-total-elimination-of-covid-19) suggests that at least the...

No kitchen implements but the usual imperial nakedness argument. There is a non-sequitur involved. 1. Exercise throughout life reduces mortality and morbidity for the great majority of people. 2. After a serious illness you are deconditioned. 3. Therefore exercise as soon as possible after a...