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  1. rvallee

    Lightning Process study in Norway - Given Ethics Approval February 2022

    Everything else being equal is such an important factor that it's drilled into every economics class and textbook. It's sprinkled all over the place, in intro classes you'll hear or read it dozens of times. And it's economics, not exactly a hard science. It's also the basis of most statistical...
  2. rvallee

    Lightning Process study in Norway - Given Ethics Approval February 2022

    I don't recognize the LP study here. I recognize the entire biopsychosocial formula universal to psychosomatic medicine. They all do this. All of them. Well, aside from the last point, where it's instead common to just make stuff up, even change outcomes to turn a null result into a false...
  3. rvallee

    Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression, 2023, Schuch et al

    Heterogenous high-bias low-quality evidence with small sample sizes about a recommandation that has been very common for years suggests maybe some effect of some sort could be perceived if one follows the standard formula that allows to do that. It says that this highly heterogenous small...
  4. rvallee

    Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression, 2023, Schuch et al

    Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression https://bjsm.bmj.com/content/57/16/1049 Objective To estimate the efficacy of exercise on depressive symptoms compared with non-active control groups and to determine the moderating...
  5. rvallee

    RNZCGP GoodFellow Unit MedCases CPD Sept 2023: Chronic fatigue syndrome/myalgic encephalomyelitis

    It is a cleverly chosen term. So generic as to be meaningless. Very political, diffuses any criticism of it as essentially invalid, because who indeed is against evidence? Which is exactly why it is so awful, even dangerous. Like a tinpot dictator making their entire propaganda about justice...
  6. rvallee

    RNZCGP GoodFellow Unit MedCases CPD Sept 2023: Chronic fatigue syndrome/myalgic encephalomyelitis

    Fully-trained LP practitioners, uh? Well, if they are fully-trained then how could it be bad? Now that's evidence-based reasoning. You wouldn't want half-trained people, that's for sure. Anyone notice the implication of "given her age" about LP? Not sure if it means that it's childish and...
  7. rvallee

    Long Covid – Into the Third Year, 2023, Timothy Meagher

    "Familiar": When you don't count some chronic illnesses as chronic illnesses, you will find fewer chronic illnesses than there are. Turns that when you don't try hard, when most in the profession are committed to denial, not much happens, especially if you insist on never doing things...
  8. rvallee

    Anomalies in the review process and interpretation of the evidence in the NICE guideline for (CFS & ME), 2023, White et al

    The revised letter is not currently published. I don't know how this is normally done, but I have sent a rapid response requesting an explanation for why my response was censored and will share the reply here. If I ever get one.
  9. rvallee

    WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome, 2023 Hwang et al

    I sent something with the help of ChatGPT. It's pretty good for stuff like this, just asking it to rewrite the message so that it preserves its intent but sounds different enough that it doesn't seem like a copy-paste. Easy peasy.
  10. rvallee

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    I don't remember exactly, but I think there was a bit more direct than that. Not "we will ruin your organization" direct, but the sub-text was clear. And she wasn't alone in this either. And as we saw with the NICE guidelines, what we see in public is just the tip of the iceberg. I wrote many...
  11. rvallee

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    I don't believe a word of that. Cochrane has given us every reason to assume their word is worthless. The review wasn't retracted because Cochrane view this as the best option for their reputation, there isn't more to it. They were loudly and publicly threatened if they did retract it, and they...
  12. rvallee

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    They were publicly cowed into backing out by loud attacks from influential MDs like Clare Gerada. She was not alone in making those threats, they were very explicit in how they meant to harm the organization if they want ahead with it. And no doubt Wessely made his own private threats, he's done...
  13. rvallee

    Exploring the mechanisms of long COVID: Insights from computational analysis of SARS-CoV-2 gene expression and symptom associations, 2023, Das, Kumar

    Browsing the site a bit: LONG COVID AND ME/CFS OVERLAPPING COMMON SYMPTOMS: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling and complex illness. Long COVID has a significant overlap in the symptoms to ME/CFS, including fatigue, unrefreshing sleep, and...
  14. rvallee

    Findings From a Survey of 530 British Antidepressant Users

    I was never told anything about it, although that may have more to do with the fact that I never really had any actual continuous care, but I'm fortunate to be in those who have fewer side effects. Mostly the damn brain zaps, but I stopped quickly several times in the past. For sure I am never...
  15. rvallee

    Preliminary clinical and cost effectiveness of augmented depression therapy versus [CBT] for the treatment of anhedonic depression, 2023, Price et al

    How I saw it covered in media: Scientists Unveil Cheaper and More Effective Depression Treatment. A promising new therapeutic approach for depression appears to be more cost-effective and potentially more effective than the existing gold standard of Cognitive Behavioural Therapy (CBT). ... If...
  16. rvallee

    Preliminary clinical and cost effectiveness of augmented depression therapy versus [CBT] for the treatment of anhedonic depression, 2023, Price et al

    For a preliminary open label trial, this is a very long paper, with a cost-effectiveness analysis, that concludes going from small preliminary trial to definitive trial in one jump. This pragmatic trial compares a new psychotherapy with CBT, so isn't actually controlled. Or I guess it's...
  17. rvallee

    Preliminary clinical and cost effectiveness of augmented depression therapy versus [CBT] for the treatment of anhedonic depression, 2023, Price et al

    Preliminary clinical and cost effectiveness of augmented depression therapy versus cognitive behavioural therapy for the treatment of anhedonic depression (ADepT): a single-centre, open-label, parallel-group, pilot, randomised, controlled trial...
  18. rvallee

    Review Posttreatment Lyme disease syndrome and myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review & comparison of pathogenesis 2023 Bai

    This framing is so bizarre. Not everyone who contracts Lyme disease is properly treated, or treated at all. It's difficult to get any diagnosis in the first place, the signs aren't always obvious, and there is a lot of denial and strongly held beliefs that discourage proper diagnosis, let alone...
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