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Yes, I doubt that the matrix proteins would show up although TGF binding protein variants might just. Regulators of interferon and TGF beta used by T cells might well turn up.

Very much so. Brain itself has very personal matrix ingredients and does not rely on collagen and elastin in the way most tissues do. But meninges have fibrillin with pinboards. And the brain is likely to have something equivalent I guess.

We have known for a long time that many EDS genotypes are defects in collagen-related genes - i.e. ECM. But the disease of elastin/fibrillin fibres is Marfan syndrome. The pinboards are on fibrillins as far as I can see.

My hunch is that the T cells would be hard to find - a bit like the night cleaners on the metro.

The first step would be to look at patterns of adsorbed signalling proteins on matrix fibres using biopsies and immunochemistry. Calibrating between individuals would probably be hard. I would look for changes in patterns. One the the best bits of evidence for our rheumatoid theory was that the...

The figures of 50-80% of people with CFS having Chiari suggest that most of these patients are even less likely to have had Chiari than ME/CFS. They just got better for some reason. It seems like the same story has had two waves of popularity. It is interesting to note that Peter Rowe thought...

I think Garner and Carson are on solid ground in their critique of 'micro-clots' which aren't even micro-clots, they are precipitates in test tubes. I think the researchers are still at the stage of trying to find out whether they have measured anything real to be honest. The story around micro...

Thread split from The itaconate shunt hypothesis A wild card theory I have toyed with for some years is that the pathogenic signalling in ME/CFS may be invisible because it is 'written on the walls' in tissue. In an underground train (metro) system, travellers need not carry any instructions...

The key thing, Chris @MelbME, is to remember not to try to teach this load of grannies to suck eggs. Or at least, by all means try - I do it all the time and I enjoy savouring the potential dents to my intellectual self-esteem that would inevitably result if I were not myself something of a...

Presumably "Retsina" is out of patent after 2500 years.

I believe it's quite common on this website when people read some threads. And violent with it.

So he believes in Psychosomatic Exertion Malaise??

I think someone is overstepping the evidence base and speculating.

Did you manage to access this @ME/CFS Skeptic ?

https://ovidsp-ovid-com.libproxy.ucl.ac.uk/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=ovft&AN=00006114-199301000-00024&PDF=y this may work @ME/CFS Skeptic but you need to paste it into the search line, otherwise you get something from El País!

I am absolutely sure that is the case. But slowing the blood won't help the brain metabolically. And if neurone are very active they may want the oxygen tension to be well up near optimal even in the venules. It may not at all like draining all the oxygen out. A bit like a Chinese paintbrush. It...

The laboratory cabinet used by Thomas Lewis when discovering the Triple Response due to histamine release.

That suggests that the tilt table test is of pretty little value as far as I can see.

It would normally but presumably if it hasn't already then there is some reason for not being able to. I don't think one can really make sense of this sort of line of thought without referring to particular cell types though. We have no idea whether any cells have mitochondrial problems let...

It doesn't really make much sense to me I am afraid. I think one would need to specify which cells were staying and which going. New cells come from old cells dividing. If the old cells were in trouble not sure why new cells would be better? Lots of cells you wouldn't want to get rid of and the...