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I just cannot see any motivation for a serious scientists to write an article like this in a journal like this - or anywhere. At least not an academic motivation.

Hasn't a clue, as I said.

an open access journal devoted to all aspects of research on human health and disease, the discovery and characterization of new therapeutic targets, therapeutic strategies, and research of naturally driven biomedicines, pharmaceuticals, and biopharmaceutical products. Topics include...

Which is worth absolutely nothing, please note!

And what exactly are, or is, 'Biomedicines' - the name of the journal? I think I understand what biomedicine means as a wide area of study that includes biology relevant to medicine, but what does the plural 'biomedicines' mean? Are there treatments called 'biomedicines' like antibiotics...

I am trying very hard to take the micro clot story seriously and the work from Caroline Dalton makes it look as if there may actually be some underlying shift in plasma protein basis to these findings, even if not actually micro clots in vivo. But this reads like someone who has lost the plot...

I have explained. I don't think we have data from studies that are reliable enough to mean much. The toxicity is considerable. The reality probably only becomes clear after watching people for twenty years. There are all sort of other practical issues likely to be weighting my view but in the...

Because the evidence to date is almost impossible to interpret and really not very convincingly positive even if taken at face value and the drug is seriously toxic. Lower dose cyclophosphamide has needed to be used chronically to have any real impact on those diseases it does help - rheumatoid...

Again it emphasises the problem with historical controls from population data. ME/CFS has a huge impact on cognition but variable. People ready to enter trials with risk are likely to be different from those who don't and maybe significantly different in natural history. I am personally not...

Yes it was. It was two out of ten, and within ten years, not a lifetime. Despite full mesna cover.

What I mean is that if natural history is unpredictable then you cannot use historical controls. You have to randomise - and make sure your randomisation isn't screwed up by drop out rates and so on.

But he said 'start you on an exercise programme'. All that needs to be said to people whether they have PEM or not (because some may turn out to have PEM later) is just take things easily and don't try to make yourself better with deliberate exercise. Someone convalescing from any illness does...

Aha, but so would I in that sense. Almost all of my research was qualitative research in the sense that I studied qualitative differences between cell populations in tissues and the immune system that did not need any numbers. Identifying the macrophage subpopulations in synovial tissue was...

Well in fact there wasn't, it was a random blip in the data that looked a bit promising but turned out to be spurious. The real problem was my fault. I pointed out to Fluge in PlosOne that in RA full remission took around 3-6 months so the 6 month data were not as unexpected as a certain Dutch...

Thanks for the lengthy reply @Evergreen. I agree that this is what it is suppose to sound as if it means but along with a lot of others here I am pretty sure it isn't intended to mean that at all. The texts mention agreeing plans, some in relation to care and some in relation to activity. My...

So where on earth does that idea come from. Why should any of these people need an exercise programme? With friends like this...

To put it another way, it is time psychologists began to understand the psychology of research. Everyone else does - biomedical, pharmacologists, physicists, ecologists,. We all understand that the simplest of experiments is mired in your own psychology or, as Feynman the physicist said, 'the...

Dear Dania, I am aware that I can be quite an abrasive critic but I have the best of intentions. I would dearly love to rescue you from this bogus view of 'research' and recruit you to actually helping people with ME/CFS. Read Brain Hughes's book: it is all in there. I have heard this...

Agreed. Alis's illustration is very useful. It makes a different point from the one about 'agreeing' to do activity but it is all coming from the same direction - justifying health care professionals' roles. When I was a locum GP and then a trainee rheumatologist in 1980 I would do domiciliary...

And so that is where the missing CBT went!