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A review from authors in Wuhan!! And published in something called 'Med' Is this AI??

It shows a complete misunderstanding of the diagnostic process. There is every reason to separate 'pneumococcal infection' from 'pneumonia' despite in many cases them applying to the same person. ME/CFS and Long Covid are different stratifying types of diagnostic category, just like 'car...

Yes. Everything is slightly non sequitur. The prognosis for LC in the first year or so may be different from ME/CFS as a whole but is may well similar to ME/CFS in the first year or so.. and so on. The desire to avoid ME/CFS guidelines seems to be at the centre of this. It is something that I...

I think IBS may have become less popular as a diagnosis with physicians, maybe because gut symptoms without any identifiable cause cover a wide spectrum. IBS is a bit like ME/CFS in being a syndrome term that covers a good number of people's clinical problems, but without clear evidence of a...

Seems a simple and sensible observation. I would like to see more attention paid to patterns over time, rather than just amounts, of activity, but in a sense this suggests a pattern, which may be worth tracking over time.

I have concluded that you are not wrong. What I don't understand is how you use measures for that. If everyone gets better does that mean you are doing fine and don't need more staff or that you need to do even better? In all my years in medicine you only ever used treatments that had reliable...

At one level I agree. But I also think that the situation is made much worse by talk of 'ME'. ME is the diagnosis that was supposed to be fictitious, and in the sense that it was linked to an epidemic at the Royal Free I think it was fictitious, but CFS is not. The use of ME/CFS makes it clear...

But marker of what? Actual clots in circulation would be expected to clear within about 1 minute max I think. If they are too small to embolise they would probably be cleared by spleen at least in half an hour. So I am unclear what this is supposed to be about.

I am not sure what you mean by clearance of micro clots? I think it swarth remembering that we have no evidence that these small structures exit in live people. They seem to occur in plasma incubated after centrifugation. The numbers of particles seem to be tiny. We see a few tiny dots. If you...

But he also said that the easiest person to fool is yourself, buddy. And strangely, although that is sort of psychology, psychologists never get it.

I haven't looked at the paper but I don't understand why they are just reporting on the posterior cingulate cortex. If their findings are specific to the PCC I am sceptical that they would be telling us something about the cause of the problem. I would expect abnormal signalling causing...

This article is actually quite interesting in relation to a conversation David and I were having in the park on Sunday. It seems that the official story about FND with DSM-5 is that it is agnostic about causation. The pundits want to reverse that. So although at one time it was hysterical...

Er, no, just a recognition that the previous view had no supporting evidence.

Having sickle cell trait/disease makes you less likely to suffer from malaria. Glucose 6 phosphate dehydrogenase deficiency and thalassaemia are other ones. People with ankylosing spondylitis are less likely to develop AIDS because of their HLA-B27.

This may be a slightly tangential issue, but it may have practical relevance. I would strongly recommend anyone writing about ME/CFS, yes ME/CFS, explicitly uses the combined acronym and also follows it initially with myalgic encephalomyelitis/chronic fatigue syndrome. If the objective is to...

Well I suppose if you had Long Covid and did a lot of exercise you might be down to 0.8 of a woman.

Not that I noticed, Dr Nath. Some slight differences in rather peripheral immunological measures in a few cases maybe. Sure there is but you didn't find any evidence for it that I could see. And nobody has found any residual antigen in any of the other conditions much (Gulf War antigen?)...

Yes, I have a faint memory of hearing that interfering with cholinergic signalling in brain produces really nasty effects but I forget which drug class.

This is all a bit complicated for me but am I right to think that maybe during 2011-2017 the Bristol group were finding 1. their studies were struggling to confirm an effect similar that claimed by PACE and 2. they were aware of increasing pressure from patients to tone down or abolish GET. The...