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This Belgian article was featured in the press: Biologisch mechanisme dat prikkelbaredarmsyndroom veroorzaakt ontrafeld | EOS Wetenschap Onderzoekers KU Leuven ontdekken mechanisme dat prikkelbaredarmsyndroom veroorzaakt | VRT NWS: nieuws If I understand correctly, the authors think that IBS...

Thanks for clarifying. There are quite a lot of proponents of behavioural interventions for ME/CFS in the guideline development group, so your testimony must have made quite an impression.

I wonder how much influence Jonathan's excellent testimony had an influence on the grading of GET/CBT trials as low to very low-quality evidence. Because his testimony was before the guideline development group but the summary and grading of evidence was prepared by other people if I understand...

If other people have a better view of this issue I'd be interested to read their books or articles. Reading tips are always welcome.

But if everybody knows about this, how come there are still little randomized-placebo-controlled trials for surgical interventions and why are many surgeons still performing the ones that haven't been tested or have been shown in RCT to be ineffective? I can't vouch for Harris his judgement but...

I've read Harris book and thought it was really interesting. I've written a blog post many of the examples he discusses (surgical procedures that were commonly performed but shown to be ineffective in randomized controlled trials). The blog post is discussed in this thread...

Would be interesting to hear if anyone knows of other examples in this list - of surgical interventions that were commonly performed and thought to be effective, only to be shown to be useless in randomized controlled trials.

Merged thread The fascinating history of surgery: when placebo-controlled trials clash with common beliefs - ME/CFS Skeptic I've made a new website for my articles and commentaries on ME/CFS research. I've just posted the first new blog post...

Posting this here: Day & Altman. BMJ Statistical Notes. Blinding in clinical trials and other studies, 2000. https://www.bmj.com/content/321/7259/504

News from the European ME Coalition (EMEC): In response to a parliamentary question by Pascal Arimont, the European Commission stated that it is working to address under-investigated conditions, of which ME/CFS is a paradigmatic example, in the first work programme of Horizon Europe. Although...

Quote from the paper: Here's a link to the Family Reported Outcome Measure (FROM‐16): https://www.cardiff.ac.uk/__data/assets/pdf_file/0006/1492323/Family-Reported-Outcome-Measure-FROM-16-English-version.pdf

Raynayd et al. COVID-19-related medical research: a metaresearch and critical appraisal https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-020-01190-w More than half of all papers on COVID-19 did not include any data or analytics (comprising expert opinion pieces).. Original...

Thanks! Looks like CFS was not included in the modelling:

Does anyone have access to this paper?

Thanks for pointing this out. Have corrected this in the original post. Apologies for any confusion!

Just noticed this statement from Moss-Morris on the website of Recovery Norway (my bolding) Rona Moss-Morris, Professor of Psychology as Applied to Medicine, Head of Health Psychology, King’s College, London, UK. Correction: the quote below is actually from Wyller. Thanks to @MSEsperanza for...

I suspect that criteria that are too broad will likely result in null results. As I understand it in most areas of medicine, researchers are usually accused of defining their inclusion criteria too strict; of selecting patients where they think treatment will work. Clinicians than usually reply...

The only randomized trial for patients diagnosed with criteria where PEM is required is the trial by Pinxsterhuis et al. 2015. It tested a self-management program based on the Energy Envelope Theory for ME/CFS patients diagnosed with the Canadian criteria. The intervention did not have any...