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(Guest Editorial) No Abstract Provided — First two paragraphs This editorial highlights two elegant articles published recently about the stress response in health and disease: Agorastos and Chrousos [1] and de Kloet and Joels [2]. Chrousos, the senior author of the first paper, is arguably...

I was rethinking about that appointment I had where I got diagnosed with FND and I remembered an interesting detail. (Note this is significant because the doctor I saw is officially a researcher in the neurological consequences of COVID, helped write the country guidelines for long COVID, and...

In the sense that they both stimulate sensory neurons, they could share the same mechanistic pathways.

That’s a good point! I’m basing this on no immune knowledge at all, but I was under the impression that cytotoxic NK cells were the ones who mainly produced cytotoxicity as opposed to other types, but yes I had not considered other types may still produce it or adapt. The body is a lot more...

That’s possible, I’m not familiar with how “cytotoxicity” is measured, is it in relation to a single cell (or an average thereof)? If yes, then you are correct. Though I would guess a lower number of cytotoxic NK cells would correlate with an average of lower cytotoxicity among NK cells.

This matches previous findings in ME/CFS of lower than normal NK cell cytotoxicity. Also random but it would be a cool feature to be able to add tags to someone else’s post. In this case would it be possible to add “cytotoxic” as a tag? cheers.

I like to think that was their reasoning behind giving that person first authorship.

I shudder to think what would happen to a very severe person in a carceral system like america’s. I imagine it would be interpreted as maligering and treated as such until the person inevitably dies from not being able to pace and feed themselves properly.

Abstract: Introduction Post COVID-19 neurological sequelae (popularly termed “Long COVID”), which include chronic sleep disruption and “brain fog” are widespread; however, studies have not yet comprehensively evaluated the concurrent effects of these disruptions of neurocognitive function and...

Abstract: Principal component analysis (PCA) is widely used to control for population structure in genome-wide association studies (GWAS). Top principal components (PCs) typically reflect population structure, but challenges arise in deciding how many PCs are needed and ensuring that PCs do not...

Abstract: Objectives Exercise capacity is decreased in diabetes mellitus due to impaired insulin sensitivity, endothelial dysfunction and mitochondrial dysfunction. The aim of the study was to evaluate the effect of metformin on exercise capacity in treatment naïve patients with type 2 diabetes...

Abstract: MCS) is still debated, which is an obstacle to assessing treatment options. An analysis of the scientific literature combined with the clinical experience can suggest some avenues. Methods: The etiology of MCS and its underlying mechanisms were reviewed from the scientific literature...

Abstract: I argue that psychiatric researchers, clinicians, and the wider public actively regulate the minds of individuals with mental disorder through the prescriptive processes of mind-shaping (see Andrews in South J Philos 53:50–67, 2015a; Andrews in Philos Explor 18(2):282–296, 2015b...

What’s the plan for the ME Association? They’ve clearly shown they aren’t willing to change. But they aren’t too friendly to the GET crowd. I mean anyone completely brainwashed by the “anti-recovery activist” narrative is going to see the ME Association as part of the “biomedical side”. And...

It’s really unfair how such a small number of people have a disproportionate cultral influence.

Whats a great use of pwME’s donated money (sarcasm)

Is that a threat to pursue legal action against the people making these accusations?

A similar comment by him on bluesky: https://bsky.app/profile/sunsopeningband.bsky.social/post/3ldiwd53mak2a

According to wikipedia Could this be related to the liver findings in the replicated blood based biomarkers study?

Revisiting this study in the context of a non-negligeable amount of recent research finding complement abnormalities in people Long COVID has my peaked my interest.