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https://www.nejm.org/doi/full/10.1056/NEJMoa2022483 Notable aspects: the highest dose (250 μg) caused headache in 100% of recipients, fever in over 50%, along with severe fatigue in some recipients of this dosage. One recipient in the lowest dosage (25 μg) group had a significant immunological...

It wouldn't say it is "quite common", but there are false positives, typically due to contamination. It's also possible that the first infection was SARS-2, it wasn't fully cleared and the second infection is something else.

It proves that no one outside of the MUS world has ever heard of the PACE trial...

Yes, but by torturing rats with electrodes...

Some interesting ideas, and definitely worth studying, but I'm not convinced the issue of pain sensation is just in the muscle spindles themselves. For example, pain thresholds in muscle fascia have been shown to be increased due to DOMS, https://pubmed.ncbi.nlm.nih.gov/25519953/ Type II...

While cerebral vessels are structurally different (thinner walled, lack external elastic lamina and thus have a lower range of contractile diameters), they do have well developed inner elastic lamina, and it is possible to have disturbed cerebrovascular myogenic reactivity...

The alternative is to consider the "validity test" themselves may lack specificity.

My father has been talking about this for years (he lives in an inner-city apartment). They need to release a product already!

The difference is probably due to travel restrictions and employers not expecting their employees to come into work when ill! ;) It remains to be seen if this proactive behaviour will remain in 2-5 years time.

Yes, I've long suspected this. Plus if there is significant latency between the infection and the illness, people will tend to ignore the infection as the cause due to the lack of a blatant temporal association.

The definition of fatigue assumed by Stokes et al. and all supramaximal twitch interpolation studies is a decline in maximal force output. This is a definition assumed by neurologists, not exercise physiologists who define fatigue as a point at which increased supraspinal drive is required to...

You hear less if the headphones are working properly. If you do something, it is likely to be a faint hiss type sound.

Ear defenders merely block the sound passively and aren't particularly effective for low frequency sound. Noise cancelling headphones actively cancel sound by measuring the ambient sound and producing an out-of phase signal, which when summed leads cancelling out the sound pressure at your ear...

The problem with all this discussion about "asymptomatic" transmission is they aren't actually asymptomatic. Such people often do have symptoms, but they don't report it. There also is an assumption by some that unless you have a fever, anosmia/hypogeusia or obvious shortness of breath, then you...

Most ME or CFS patients weren't ready to accept such a diagnosis after experiencing similar patterns of illness for 3-4 months and the CFS diagnosis is toxic. So I can certainly understand the strong reluctance.

Superordinate Theme: researcher confirmation bias. Note strong participation bias (these findings are not generalisable to all patients):

It depends on what you count as a study - there have been methods/review papers, case studies, clinical data studies and case-control studies. If you include all primary studies including the case studies, we're at 13, although one of those had overlapping data with another (van Campen et 2020...

Hah. It's surprising when neurologists talk about "effort" in this way, yet they have no idea what it is. I mean there is over 150 years of research on it (back to Helmholtz's experiments), and they haven't bothered to talk to exercise physiologists either. Instead they have decided to ignore...

By "looking inward", does that mean they are going to do experiments to study scientists themselves?