Search results

This is a rather alarming and saddening conclusion!

It is notable that they never contest the fundamental methodological issues directly.

Reminds me of the glucose analogy that a certain someone likes to mention occasionally...

Interesting, that there were very few predictors of (incident) CFS and none of them had particularly large odds ratios.

I have a great deal of sympathy for newly ill patients who are not medical doctors, but MDs should know better.

Not uncommon, yet I still feel angry when I read of medical malpractice like this...

Glad this is finally off the ground! A quick question, will participants be able to access a set of their own genome data? This (at least in my opinion) would provide a strong incentive to be a part of the study.

Ugh, the nasal flu vaccine is trash. It's not approved for use in Australia for good reason! The rest of the article is not totally coherent, mentioning non specific "baseline inflammation" without explanation. The claims that the vaccine won't work for the older population is still pure...

His argument about elderly individuals is a non-sequitur. The reason why we have to test vaccines directly, is because seroconversion/antibody titres is not enough evidence to show the vaccine actually works. This is doubly so for SARS-2 vaccines, which are testing a variety of new and unproven...

There are only two ways to test the real-world efficacy of vaccines, a naturalistic randomised controlled study where you recruit a large population (tens of thousands of people) but only vaccinate half of them, and hope that many of them will be exposed to the infection. The other is to...

It's not any single thing that I'm looking for, but a list and hopefully we might spot some clear patterns.

Part 2: Integrins are also common viral entry points (including herpesviruses and picornaviruses, Q fever, Ross River virus etc). SARS‐COV‐2 and infectivity: Possible increase in infectivity associated to integrin motif expression https://onlinelibrary.wiley.com/doi/10.1002/jmv.25831 A...

I'd like to propose a thought experiment for all you s4me people, starting with what do EBV and SARS-2 (or SARS-1) have in common in terms of infecting cells and causing disease?

Neuropilin-1 is a host factor for SARS-CoV-2 infection James L. Daly, Boris Simonetti, Carlos Antón-Plágaro, Maia Kavanagh Williamson, Deborah K. Shoemark, Lorena Simón-Gracia, Katja Klein, Michael Bauer, Reka Hollandi, Urs F. Greber, Peter Horvath, Richard B. Sessions, Ari Helenius, Julian A...

Yes, much of this is known already and doesn't confirm the presence of a certain hypothesised metabolic trap.

The acute responses to exercise were interesting, but I'm sure we would have appreciated longer testing, namely 24 and 48 hours!

Wow, it'd help if they isolated it down to one of those extracts. It's impossible to say what would be the relevant bioactive compound from that long list!

(I apologise if this seems to be a little obscure). Animal models suggest a relationship between dystrophin and muscle fibre fatiguability. Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications...

Optimal "fat utilisation" only matters if your goal of exercise is to lose fat! If you want to increase strength or fitness, unfortunately the only way to do so is through intense activity. But keep in mind this intensity can be extremely brief - it is about quality, not quantity.

Notably, they did publish the actual questions in the manuscript, but they're the usual nonsense. Each question has a short blurb to guide the scorer on severity. Note the bit "Disregard any statement about the cause being organic." mhmm. Also, I've never heard the words "micturition" or...