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The problem is, that it doesn't really explain anything. How are the "non-essential energy-consuming processes are throttled down"?

Is it really that curious? A large majority do not report significant improvement or recovery and there are no controlled studies to suggest it isn't simply spontaneous remission. It is also hypothetically possible that the immune stimulus itself was enough for the body to sort itself out in the...

Yes, both sorts of hypotheses have been made for a variety of conditions over the last few decades. There still seems to be a lack of strong evidence, despite the popularity of these hypotheses.

We have to perform more studies to find out, but I detailed several general explanations in my previous post.

Is this the first questionnaire used for ME/CFS patients where they have bothered (or are planning) to test face validity?

If he used a juice fast or homeopathy during his spontaneous recovery, would people be taking him so seriously?

Besides age and sex (and hormonal variances), there is likely some degree of genetic variance (and an effect of fitness, but this can sometimes increase the maximum heart rate in the less conditioned!) Exercising to one's true maximal heartrate is hard for someone with ME/CFS. It requires...

This also reminds me of the people who were asking whether participants were already suffering from PEM during the first test. So in that case it is a question of how much is needed to further exacerbate. Some participants (depending on underlying fitness and health) may need to do a higher...

Graded Exercise Therapy is technically still a Cognitive-Behavioural Therapy, albeit one that focuses primarily on behaviour. A pure exercise therapy focusing on reversing deconditioning would focus on intensity, rather than merely duration and would explicitly factor in rest days, rather than...

A very high RER (>1.2) suggests significant hyperventilation. This could be due to a high rate of respiratory compensation. Unless it was a transient spike, or the equipment is somehow not calibrated properly, it is probably not an equipment problem.

I'd also argue that evidence of central fatigue is also strong for CFS, though the underlying cause of that central fatigue is debated (and sadly, often debated by people who understand very little of the physiology) The consistent finding is reduced workload (usually measured in watts) at the...

The former. Deconditioning simply means lower performance at a given heart rate. I don't think it is deconditioning. Having ME/CFS means it is more difficult to exercise if you are not used to it, and it will feel like your legs can't work any harder. Some people may think that this is their...

Either that, or your body is broken!

VO2Peak can still increase while RER plateaus by increasing ventilation and delivery of that oxygen to the muscle (eg by achieving a higher heart rate or higher blood pressure). But more to the point, how many participants didn't achieve an RER of 1.1? We don't know. Note that the ICF cases...

Or there is a true effect. Another study by this clinic provides more detail on the diagnostic process: https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02397-7.pdf Unfortunately this level of detail was not stated for the current CPET studies. Though it's quite...

It's more than just the last week or two that is important to consider. Notably, in Mongolia, they're now trying to secure supply of the Pfizer vaccine to be offered as boosters...

No. I think it is due having double the number of participants and is more reflective of real-world variability during the test (also given that I don't believe all participants worked hard enough to achieve a true VO2 Max).

I'd rather demonstrate the difference with electromyography, MR spectroscopy, doppler flowmetery (and even pharmacological nerve blockade), rather than a nightmarish scenario of daily maximal CPETs! Even if the CPETs are not maximal, it is still a strong ask of patients.

Same, it is only a problem when suffering from PEM and I find it hard to concentrate.

I still sweat and shiver. ¯\_(ツ)_/¯