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Do you think living in a tribal scenario, living without permanent shelter, relying on insecure food sources and potentially under threat from warfare is any less stressful? What is a "normal" level of cortisol or adrenaline?

They think PEM is Boom-bust! ;) Also note the boom-bust categorisation was post-hoc.

It's Alexandra Elbakyan and you can block components of a website with ublock origin (Chrome based browsers) or similar in other browsers.

I doubt it. There is also another study claiming that coronavirus immunity is not maintained. https://www.medrxiv.org/content/10.1101/2020.05.11.20086439v1 The serological findings suggest that where there is significant genetic variation of the antigenic proteins, immunity is not maintained...

Sigh. Wyller has repeatedly tested and failed to find an empirical foundation for his "sustained arousal" hypothesis. I suggest the same will be true for the "Lightning Process".

The problem with HRV as a measure is the underlying causes are very non-specific. Reduced fitness itself can explain the difference between patients and controls and reduced fitness is a likely consequence of greater severity of the underlying illness. Mere association is not enough to derive...

I was thinking which would I rather do, and the answer is none of them, but I guess I'd rather do the 6MWT, followed by this test, followed by the step test followed by the CPET in last place if forced to make a choice. The protocol: Also, on second reading, I note the curious omission of the...

That is not what was shown though. This is not a specific biomarker. It is difficult to control for effort (and difficult to directly examine the coupling between peripheral and central fatigue), so it is easy for researchers, including the authors of this thesis to simply conclude that the...

Hypotheses of fatigue are discussed, though managed to overlook the endothelial dysfunction hypothesis - an aspect that could be shared between CRF and CFS. The usual (questionable) demarcation between central and peripheral fatigue that ignores any couplings between metabolism and regulation of...

Yes, and I've always wondered why!

Interesting that he believes that. Fatigue is not an alarm signal. This has got to be one of the most common myths of all and professionals who continue to believe this, clearly they are not critical thinkers. Severe pain is the alarm signal. There is no need for any other. So it is clear...

Time for a poll? I have chronic rhinitis, but I didn't think everyone had it.

These factors on their own shouldn't explain the difference, hence we can strongly suggest there are participation biases in this study and the results are not representative of the general public.

Presumably plants must be suffering from negative thoughts before they are infected with plant viruses.

I might have time to explain in more detail later, but for now: We cannot conclude either way, due to flawed testing/modelling. It is important to point out three aspects: (a) people feel fatigue at far lower levels of exertion and only rarely exert maximally hence the body never relies on a...

Note, the first author is Georgina Newton (not to be confused with Julia Newton) along with colleagues at the School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham. I disagree on (c) and (d). The problem is the wrong instruments have been used for (c) (supramaximal...

Pity this yak dung effect doesn't translate well to humans.

Almost nothing in the "self perpetuating spiral" has been demonstrated as leading to the next step.

This is an interesting proposal, but I note with caution that due to significant variations in daily activities, it can be difficult to separate the noise from the signal, unless they use long sampling times, or a large sample size. As such, the feasibility study will simply demonstrate that the...

Classic neuro-babble.