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I can completely understand why many researchers are currently focusing more on going after a persistent SARS-COV-2 virus rather than something like EBV. First of all there are actually mAbs for SARS-COV-2 as well as many different antivirals, with different mAbs and antivirals being in...

Neurologic Effects of SARS-CoV-2 Transmitted among Dogs Abstract SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine...

Thanks, but I'm not sure if that does answer the question, I think I just know too little about the subject. For homosexuality being viewed as psychological disorder and then treated with "conversion therapy" very similar beliefs were present and there is a Freud connection as well as a...

What is the etymology of the terminology "conversion disorder"? Is it related to the same medical professionals and/or disciples that used to be certain that for example "homosexuality" was a psychological disorder that could be effectively cured with "conversion therapy"?

Prefrontal dysfunction in post-COVID-19 hyposmia: an EEG/fNIRS study Introduction: Subtle cognitive dysfunction and mental fatigue are frequent after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, characterizing the so-called long COVID-19 syndrome. This study aimed to...

Agree with what the two others have said. Technically most Long-Covid research is probably to a large extent just post-viral fatigue research (of course Covid-19 is still a very special virus) since a majority of the studies just ask patients how they are feeling at 4 weeks post-infection and...

Personally my guess on what ME/CFS is change throughout time depending on my personal bias of my own lived experiences and is even more so driven by the bias of which research has recently been published. The only thing I know for sure is that there isn't a simple explanation and studies looking...

Brain fog in long COVID: A glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism Abstract Brain [18F]FDG-PET scans have revealed a glucose hypometabolic pattern in patients with long COVID. This hypometabolism might reflect primary astrocyte...

There has been a bit of discussion about Iwasaki's paper here and what lower cortisol could be indicative of. The sample sizes here are a lot smaller, but could still be able to add something to that discussion with lower cortisol levels only being noticeable in the mild/moderate female (edit...

Link to the published paper ******* Sex and disease severity-based analysis of steroid hormones in ME/CFS Preprint Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by decreased daily activity and persistent fatigue after physical...

A team in Germany is planning to launch a trial with the drug IMU-838 trial for Long Covid. Currently there aren’t too many details on the trial, however Maria Vehreschild of the Universitätsklinikum Frankfurt has given some details in this talk www.vimeo.com/873993707/description (from 32:30...

In my eyes it's good, I highly doubt the trial will yield any positive results (it's only an exploratory study), but unfortunately that is just the way it is. The disappointing part of the trial is that it isn’t placebo controlled, I don’t see a reason why one wouldn’t do that.

HIV to me seems like a bad example, firstly it doesn’t seem comparable to COVID-19 and is quite a “special” virus, secondly because it usually doesn’t cause symptoms related to post-viral illnesses albeit infecting cells all over the body and thirdly because it's extremely progressive if not...

Thank you! I saw the number of healthy controls but couldn't find the number of patients with Covid.

Thank you for sharing and summarising @SNT Gatchaman. Do you have details on the sample size?

As we all know viral persistence is possibly the leading hypothesis currently driving Long Covid research. There's generally two concepts on how the virus could be persisting. On the one hand via some form of viral reservoir (possibly replication competent, possibly non-cytolytic or via some...

Uses flow-mediated dilation, which is very similar to EndoPat used by other groups. A significant problem (in drawing a comparison to HC) here are the large differences in weight/BMI between the ill and healthy patients, with the BMI for LC being at 34.19, for ME/CFS at 31.49, and for HC at...

People With Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Exhibit Similarly Impaired Vascular Function Background This study aimed to compare flow-mediated dilation values between individuals with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome...

Clifford J. Rosen is the Principal Investigator for the MaineHealth RECOVER site. According to healthrising "An editor for the New England Journal of Medicine, Rosen stated that he wasn’t seeing many good long-COVID papers (ouch!) and actually made a pitch for people at the conference to submit...

On Gerrit Keferstein (translated): "Through his intensive self-study with literature, further education, networking and exchange, he came across an elementary explanation of previously unknown connections between environmental influences and chronic diseases: Mitochondrial energy production...