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Given some of the recent genetic findings on Raynaud’s I was wondering if that is somehow partially assessed in one of the DecodeME questionnaires (I fully understand that there’s also a rather smaller upper limit to what can be assessed)?

There seems to a lot of stuff going on this front at least if I'm to trust newsreport headlines. In particular continuous lactate measurement devices (continuous lactate monitors) are starting to become a popular topic especially in professional sports such as cycling...

Considering the lack of any meaningful scientific rigor displayed in different subfields of psychology and psychiatry by some influential researchers it isn’t surprising that exactly these fields currently have a massive replication crisis and a long history of “wrong and harmful statements that...

This group wrote a series of papers on this topic. Another one was discussed here.

cerebral blood flow [27,28,29] - I've always thought these findings are very interesting but they are findings from one group of doctors that only do this experiment in their own practice and this experiment is sort of the selling point of their practice. Unfortunately, as of today the findings...

I don’t know how this could be a fruitful direction of research, especially when something has 0 influence on the quality of life since it can easily be avoided. Furthermore people with LC or ME often have some form of brain dysfunction and/or gut problems and often even headaches so it wouldn’t...

I also think studying blood regulation seems like a very useful approach and I think there should also be some novel ideas to try to understand whether autoimmunity plays a part in ME/CFS, but I don't think that every research that somehow looks at autoimmunity should be focused solely on...

Persistence of an infectious form of SARS-CoV-2 post protease inhibitor treatment of permissive cells in vitro Reports have described SARS-CoV-2 rebound in COVID-19 patients treated with nirmatrelvir, a 3CL protease inhibitor. The cause remains a mystery, although drug resistance, re-infection...

This is peak shithousery commonly witnessed amongst such groups financially profiting from the products they advertise: I am part of said group -> Everything they do is perfect, it's "science", no questions allowed. I am not part of said group anymore -> Everything they do is harmful, follow me...

I struggle to see how such a model bares any relevance to reality. The modelling of the noise, which is the essence of the model, is completely arbitrary. They want to see some basic dynamics, so they just use an SDE with constant diffusion. My guess is that the authors were very motivated by...

No, you just have to fill out your name in the google doc form, several researchers and organisations as well as patients that aren't US citizens/taxpayers have signed. It would also be possible for S4ME to sign the letter as organisation (I guess that would require the members/board to...

Same team that published opposing results in https://www.sciencedirect.com/science/article/pii/S0889159123000065?via%3Dihub.

Cerebrospinal fluid findings in patients with neurological manifestations in post-COVID-19 syndrome Background Information on cerebrospinal fluid (CSF) findings in patients with neurological manifestations in post-COVID-19 syndrome is scarce. Methods Retrospective evaluation of 84 CSF samples...

Indeed. I was also disappointed by the lack of signatures of patients. Certainly signatures of researchers, clinicans and organisations are far more important but not even getting anywhere close to 1000 patient/ally signatures is somewhat disappointing. Wouldn't be surpised if this letter...

I don’t have any expertise to judge such work, but I feel like a lot goes missing when you’re studying a persistent infection in-vitro without evidence of it existing in-vivo. After all the persistency is supposed to be taken care of by complex immune systemic mechanisms which could probably be...

Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model Highlights Persistent SARS-CoV-2 infection model of human cardiac tissue was established Hypoxic stress to the persistent infection model led to cardiac dysfunction ACE2 and...

Paper has now been published in JCI Insight - https://insight.jci.org/articles/view/166540#F4.

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Abstract To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and...

Just like the rest of the paper unfortunately. 15 authors for a mundane review full of errors passes peer review, are they all just bots?

Enough internet for today...