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To me that's more of an artefact on what ME/CFS researchers have decided to be the best solution. Simultaneous research and drug trials has become a much hotter topic than it used to be, the same holds for the Long-Covid field. Drug trials to figure out a biomarker, rather than biomarkers to...

Logically if Nath would have strong findings in ME/CFS he would have tried to see if the same holds in a similar subset of Long-Covid patients or at least the younger research members in his team would have tried to get grants for this. Their published Long-Covid findings and also the one...

I'm not getting my hopes up too much on the intramural study. Usually, when researchers really have found some true breakthrough results they try to make that public quicker than is the case here and it doesn't seem like follow-up projects are planned. I think it'll be one of those "we found...

The message I got was the paper has been submitted for publication (some time in April/May). Which just means that it'll take anywhere from a couple of weeks (probably not since it's a big paper) up to roughly a year for it to be published from that time point onwards. All subsequent...

The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus e.g. SARS-CoV-2 in long COVID patient's tissues, immune dysregulation with or...

Upps, spelling error. NSGK should be NKSG https://cfc.charite.de/klinische_studien/nksg/. I'll change it above.

I've been told the current platform consists of EndoPAT, RVA, fMRI, a belt test (something for endothelial function) and of course your blood results. So mainly things that look at endothelial dysfunction, which makes sense given their Vericiguat trials. OCT-A doesn't seem to be part of it yet...

This study being based on the study by Bouquet et al. means that the sample sizes are very small (ME/CFS (according to CCC) n=14, HC n=11). However, a re-analysis of other studies based on similar methods should be possible.

ME/CFS is a debilitating disease with obscure aetiology. However, despite the extensive amount of research that has been performed on the transcriptomes of ME/CFS patients, all of them are solely focused on linear RNAs, and the profiling of circRNAs in ME/CFS has been completely omitted. In this...

Has anybody had a closer look at Meplazumab, https://clinicaltrials.gov/ct2/show/NCT05813587?term=Meplazumab&draw=2&rank=8, before?

"Furthermore, it is possible that some individuals in the comparison group had SARS-CoV-2 infection that was not detected by a PCR test. This risk was reduced by excluding from the analyses 53,530 participants who had only negative PCR tests recorded but who reported that they had had SARS-CoV-2...

I'm not particularly fond of the Metformin trial for people with a normal BMI. However, if it is convincing enough for people to prove that Long-Covid isn't psychological or is the last bit of evidence they needed to reach that conclusion, as suggested in this newly published paper "The...

It seems like Douglas Fraser et al. always choose the same group of patients that don't seem to represent the "classical" Long-Covid patients (predominantly female and younger patients), but rather those that seem to suffer from acute Covid more (predominantly older, a slight majority of males...