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With respect to patients having to have an infectious onset as well there being a time-limit for illness duration, I'm going to break a lance for the researchers conducting the study. I can see why one could do this. I haven't followed ME/CFS research half as long as most other people on this...

Well done @Grigor! I tried to scrutinize it to my very limited abilities, but there isn't anything I can criticise. I do believe the sentence "As a result, the term 'Exercise is Medicine' may not be directly applicable post-COVID condition patients exhibiting PEM. (1,3)" is missing a "to"...

@Manuel is Manuel Ruiz Pablos.

This doesn’t seem particularly specific to neuropathy though or if so why would that be the case? Any ideas how to do things differently?

This is just a short abstract, probably from a conference, with a sample size that is negligible (especially since the larger studies by Scheibenbogen and others don't exactly confirm such results), but apparently a larger study is underway www.twitter.com/Dysautonomia/status/1722698048738910323.

Abstract 16323: Functional Autoantibody Analysis in Post-Acute Sequela of COVID-19 Patients With and Without Pots: A Case Control Study Abstract Introduction: Post-Acute Sequela of COVID-19 (PASC) occurs after recovery from the initial illness. Autonomic dysfunction (AD) may explain these...

Ignoring the unblinded treatment, the CPET results and the small sample size, which all don't seem too meaningful, from what I've understood, your more general point of criticism is mainly in regards to SFN and how it is diagnosed based on counting some lines under a microscope via a tissue...

The intramural study will be published in Nature Communications www.twitter.com/oslersweb/status/1722330356458693033. To me that sounds like a confirmation that they didn't find much, or at least not as much as some patients are hoping for.

Indeed (the price just for your PhD student to have an office desk is already beyond CA$20.000 per year in NL), these are two different things. Jeroen den Dunnen has funding for a PhD position (possibly as part of his ME/CFS grant by ZonMW) which he is now advertising...

Pre-print Small Fiber Neuropathy after COVID-19: A Key to Long COVID Abstract Objectives: Report a case series of new onset small fiber neuropathy (SFN) after COVID-19 treated with intravenous immunoglobulin (IVIG). SFN is a critical objective finding in long COVID and amenable to treatment...

Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of mental health symptoms in patients with post-acute sequelae of SARS-CoV-2 infection (PASC) INTRODUCTION Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...

(this sentence structure is a bit confusing to me, what they are saying is that the infected COVID-19 group is younger at 56.04 years compared to the uninfected controls with 58.1 years) The massive caviat is that this study is extremely focused on the male population with only 7.8% of controls...

ASSESSMENT AND CHARACTERIZATION OF COVID-19 RELATED COGNITIVE DECLINE: RESULTS FROM A NATURAL EXPERIMENT Background: Cognitive impairment is the most common and disabling manifestation of post-acute sequelae of SARS-CoV-2. There is an urgent need for the application of more stringent methods...

Their preprint predates the work of Peluso et al by a couple of months so I suppose they can claim being the "first ones".

First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody Abstract With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is...

A classical Ruud Raijmakers review. A lot of focus on that an ME/CFS diagnosis leads to a worse outcome, instead of having ME/CFS that leads to this outcome, “strengthens the poor prognosis that ME/CFS diagnosis” have. Raijmakers probably also thinks "AIDS is a harmless syndrome, however a...

Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors Background As a debilitating condition that can impact a whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever...

Maybe someone has a clever question or 2 for Amy Proal that they want to ask. “What would you ask Dr. Amy Proal about Long COVID research?” www.twitter.com/dsethlewis/status/1720576399528886307 www.reddit.com/r/covidlonghaulers/comments/17ndh79/what_would_you_ask_dr_amy_proal_about_long_covid/

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise Editor’s summary Regulatory T cells (Tregs) support repair of injured muscle, but whether they participate in the response of healthy muscle to exercise training remains...

There are two very different arguments. On the one hand there’s the possibility of ME/CFS having different downstream effects, having different subtypes or even being a collection of different illnesses. This seems like an extremely reasonable hypothesis to me for which the very reasonable...