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Another thing is that we now have a South African variant which the AstraZeneca is 10% effective against i.e. 90% still get symptomatic disease. So maybe the South African variant can still be transmitted by people who've been vaccinated with AstraZeneca - transmission in the community is...

Got this reply from my MP: "Thanks for getting in touch to raise this. We can certainly ask a written question about the issue to the Secretary of State for Health, but perhaps you think it may be best raised via the Public Accounts Committee. They can be contacted via this email...

Brilliant - thanks for the laugh & the insight @Snow Leopard I've just had the AstraZenica vaccine and to adjust the phrase --- a (AstraZenica) vaccine in the arm is better than none (other option). I'm getting a bit --- off that they seem incapable of following the rules --- first the...

Thanks for your comments @Snow Leopard they remind me of @Jonathan Edwards comment "When I acted as MRC advisor this recent time around the GWAS project was the one thing that looked worthwhile, apart from maybe some actimetry studies."...

I was a (failed) science technician back in the day and one of my jobs was to test sick swans for lead poisoning. The levels were pretty horrendous; I fleeting thought they must have had enough to act as ballast. Heard recently that the "voluntary" code (non-toxic shot over wetlands) has failed...

Looks like a comedy sketch! If they had objective measures at the start and subjective measurements at the end (and we know that subjective outcome monitoring overestimates activity) then that's a pretty neat (apologies) way to cook the books. If they'd used subjective indicators...

Thanks @dave30th could you explain what "HRA" is? If I can get this moving (unlikely) then it may be useful to have details of the project/study protocol (links etc.).

Split thread @Colin If you check out some of the OMF Community Symposium's you'll see the results of a study of metals in people with ME. From memory: one person had high mercury and they ate a lot of (pacific?) salmon; pacific salmon are long lived and bioaccumulate mercury. A couple of people...

Finally emailed my MP i.e. to try to raise the change in the methodology (outcome indicators - objective to subjective) in the PACE protocol. If there's revised NICE guidance, which (at least in part) undoes the mistake, then this may be an opportune time to remind Government of the need to...

I agree i.e. about +ve scoring (by patients) when subjective outcomes measures (questionnaires) are used: It's about being interested in making their (people with ME) lives better - that's why people score the intervention positively - the person (health care professional) is showing an interest...

There was an interview with Tim Spector on Radio 4 recently - The Spark https://www.bbc.co.uk/programmes/m000rlpz There were a few awkward pauses, re his new company venture, which I felt indicated he'd decided to monetise his ideas --- get some cash in the bank --- gone over to the dark side.

There's an excellent review by @Jonathan Edwards of the current position re ME/CFS research here: https://www.s4me.info/threads/the-true-nature-of-an-autoimmune-disease-leisk-and-nocon-2021.19583/page-3#post-332763 In a way it illustrates the difficulty in developing any GRADE type assessment...

On the plus side (joke): "Improving Access to Psychological Therapies (IAPT) programme. Clark (2018) reported that 50% of people receiving IAPT recover and two-thirds show significant improvement." OK that (presumably - can't access the cited study*) is what the patients reported in the...

Yea it's sad at some level that we have to rely to translators like @Jonathan Edwards - grateful for the insight though.

I don't follow this crap carefully so I may be off message here. This bit jumped out at me "may lead users away from ‘real life’ social support, therapeutic engagement and effective, evidence-based interventions". Basically I read this as we've cornered the market in Shamanism come over to us...

Excuse my unkindness, but if they've got to the point that we just have to be concerned about the proof reading, then that's a quantum level leap for them. Didn't read the letter - perhaps I will. See SOLVE is working with them - I've a lot of respect for SOLVE, so maybe things are better.

EDIT - just realised you mean biomedical research so had to redraft ("charlatans" removed etc!)! Obviously there's a question of the validity of the outcome measure. You really shouldn't use subject indicators, i.e. questionnaires, you should use objective outcomes i.e. activity monitors. You...

Yea reminds me of an "issue" re fish length/weight --- the data causing "concern" didn't show the seasonal effect --- if your going to cheat then you actually need to have a good understanding of what you should find!

I've had a memorable burger --- bacon --- cheese --- in Queenstown South Island. Can't see why you guys would eat McDonalds --- OK it's cheap. You've also got green mussels -- probably the best mussels in the world Ever get back there I've a list of eats --- elephant fish with chips ---

Happened to glance at the packet of chicken thighs - tonight's dinner - £3.60/2KG or 90 pence for 2 portions (500 grams). OK I go overboard by filleting them and cooking the meat/skin/bone separately in an air fryer. But yes it is cheap. Pre-covid, before I adopted drive through click and...