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Someone blessed with good health ---you too could be like me --- if you pay for X. Y, Z---distasteful!

I wonder if part of the problem here is that Universities expect researchers to bring in money oh and some researchers might want to earn some extra cash. I haven't been following this closely so I had to Google "ebm programme at mcmaster university" laughed/gritted my teeth/shook my head when...

Yip "right" but not "right enough" sums it up! However, in this case it's those who oppose the revised guidance who have to go through the court ---. I work in planning policy [UK devolved administration] but I'm not a signed up believer --- more a failed chemistry technician actually!

I was only commenting generally e.g. if you found out that the brother in law, of the person making a decision, benefitted from that particular outcome, then I assume the Court would grant a judicial review - in effect voiding the guidance. I don't follow this issue closely but people in...

I'm no expert but part of the difficult here is the question the court asks e.g. is the decision so perverse that no reasonable person could come to that conclusion based on the evidence? Or e.g. is the decision void because the decision maker was not independent - conflict of interest? That's...

I'm no expert, and I haven't even followed this closely, but I wouldn't recommend that the psychological bunch challenged the revised NICE guidance. I think they'd have to prove that no reasonable person could possibly come to that conclusion [Wednesbury unreasonable] --- a difficult argument...

Thanks @Jonathan Edwards From the outside these people seem to be relying on something akin to religion i.e. they have a truth but it cannot be measured -- we'll it can but the base objective measurements don't confirm the truth so they have to be cast aside in favour of the subjective ---...

Thanks & for the laugh - as always!

Way above my head too. I'm not sure if this post by @Jonathan Edwards is in any way related to this publication [they both suggest immune dysregulation I guess]: https://www.s4me.info/threads/me-cfs-funding-worsens-as-nih-maintains-status-quo.12949/page-2#post-228586 The other thing is that I...

Perhaps broad criteria are OK in a biomarker study; if you filtered too much then you could exclude people who provide insight into the disease mechanism.

Seems to provide evidence for going with a single dose --- reduction in hospitalisations 95%? I wonder if this will encourage the the UK Westminster Government to further delay second doses i.e. to get more people a first dose. Still, only sure approach to avoid severe illness/death is not...

My prejudiced view is that some of these peoples social circles/establishment friends might be avoiding publicly supporting them --- but maybe I'm wrong on that!

With a bit of luck: fingers have been burnt. Including the public servants who were involved in this [PACE] project and, indeed, it's subsequent adoption as Government policy; and politicians will be aware of the risk of associating themselves with these dodgy psychosocial theories - can't be...

Here's an extract but it's all pretty daming. “Although we originally planned to use actigraphy as an outcome measure, as well as a baseline measure, we decided that a test that required participants to wear an actometer around their ankle for a week was too great a burden at the end of the...

I wonder if that could be highlighted in the media i.e. if the objective activity monitoring was dropped - pretty damning! By the way who dropped the activity monitoring i.e. the "researchers" or the civil servants/Government? If there's a link to the specific text then I'd be interested. Can't...

But surely "all studies gave the same direction and because the observed heterogeneity (80%) was mainly caused by a single outlier" suggests that in an unblinded intervention, with subjective outcomes (questionnaires), the Hawthorne effect is consistent - people respond positively to attention...

Thank you. "meaningless games with words and statistics" --- "It is not clear that patients' self-perception has actually changed, or just their scoring behaviour, which are two different things." seems to sum it up - damming. EDIT - if the intervention doesn't work, and the exercise...

So a study which found a negative outcome [ability to return to work] was adopted as the basis for Government policy. I'm tempted to say unbelievable - but then it (unfortunately) is believable. I've previously highlighted the old internal joke about the Governments official line being "evidence...

The other thing is that there doesn't appear to a good reason to rely on crap studies/methodology i.e. to assess whether an intervention works. E.g. Fluge, and Mella, used activity monitors to assess rituximab. So rather than defending poor studies they could spend some time looking at objective...

Don't know much either but transcription means making a protein - post transcription means the protein is altered after transcription. I kind of recall a talk Jonas Bergquist did a few years back i.e. on proteomics. Basically the body make a remarkably few proteins (maybe 40K) but post...