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  1. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    Really, David, I thought you were a well read man of letters. Ralph Waldo Emerson: A [certain? - sources vary] foolish consistency is the hobgoblin of little minds'. He attributed it to statesmen and religious folk but there is no lack of it in medicine and science.
  2. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    Indeed. I am constantly reminded of Emerson's ' A foolish consistency...
  3. Jonathan Edwards

    O'Dowd-Crawley early intervention study

    This is an interesting suggestion. In days gone by I would not have doubted it for a minute. But things are changing and one could argue that nobody owns data if it is in the public domain and is of public interest in terms of medical implications. I think this would be a very interesting test...
  4. Jonathan Edwards

    Investigation into cognitive behavioural therapy for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, 2020, Clark

    This suggests that the active ingredient is a 'therapy room' - maybe the wallpaper. So maybe not the cardigan?:( Good to disprove a theory though.
  5. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    You would have thought so, but not in this field. For a professor in the field to not understand this or deliberately obfuscate seems to me less being misguided and more incompetent. I have a terrible suspicion that part of the descent of medicine into this sort of post truth situation is to...
  6. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    As far as I can see 'validation' means nothing other than that you get the same sort of answers on several trials. It means a questionnaire is probably being adequately understood. Nothing more. It has nothing to do with validation of the measures in the sense most people would think of. Anyone...
  7. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    At least the second part of this sentence seems fair. I agree that validation means nothing much more than that people who speak English can understand the questions. Subjective endpoints are to be preferred if they reflect key features of distress or disability. But that is irrelevant if they...
  8. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    He seems to be a psychogeriatrician from King's moved to UCL.
  9. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    I agree that the whole thing is very complicated and counterintuitive. I got at least one thing wrong last time I tried to give some explanations. To me the most likely thing is that for treatments that work adequate blinding tends to be used. For treatments that don't, people use inadequate...
  10. Jonathan Edwards

    United Kingdom: News from BACME - British Association of Clinicians in ME/CFS

    That doesn't stop them from joining a proper website like this one.
  11. Jonathan Edwards

    University of Victoria (Canada) article on development of EEG wearable

    Tests of this sort are only any better than asking people how they are either if they have been shown to provide some sort of explanation in terms of physiology or shown to predict symptoms later -and usually both go together. Correlation in a test is not in itself a sign of usefulness, even if...
  12. Jonathan Edwards

    University of Victoria (Canada) article on development of EEG wearable

    This is nonsense. The idea that an EEG is more reliable than you are to tell if you are fatigued is plain stupid. Being fatigue is defined by what it is like to you, not EEG. EEGs are completely useless for diagnosing anything of this sort.
  13. Jonathan Edwards

    United Kingdom: News from BACME - British Association of Clinicians in ME/CFS

    We have based our interventions to date on this original research andour experience tells us that they work. However, these Interventions have been embedded at Vitality360 within a multidisciplinary approach and not used in isolation. What we have learnt from the research and our experience is...
  14. Jonathan Edwards

    United Kingdom: News from BACME - British Association of Clinicians in ME/CFS

    Another CV below. Who are Vitality360 then? If anyone has reason to think they are not commercial quackery I would be interested to hear.
  15. Jonathan Edwards

    United Kingdom: News from BACME - British Association of Clinicians in ME/CFS

    Is anyone who is a member of BACME a member here on S4ME? If not why not, since this is the premier forum for discussing evidence based treatments? I checked out one of the speakers: About I have spent over 20 years working as an Occupational Therapist in the NHS, helping people maximise...
  16. Jonathan Edwards

    Chronic Lyme Disease: a discussion of the epidemiological data

    There is also a much larger medical community of well-qualified and well-informed doctors who agree with Michiel's conclusions.
  17. Jonathan Edwards

    Protocol: Persistent physical symptoms reduction intervention: a system change and evaluation (PRINCE), 2015 onwards, Chalder, Moss-Morris, et al

    So this is why the BMJ is casting doubt on the need for blinding this week. What a shabby circus medicine has descended to.
  18. Jonathan Edwards

    Bias due to a lack of blinding: a discussion

    I think it may be very relevant that the 18 Cochrane reviews mentioned above are pretty much all looking at rather obscure interventions that are pretty unlikely to have any great value in the long term. They are fiddling around the edges interventions, not because the conditions being treated...
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