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Abstract Background: The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-dependent manner. Interaction between kynurenine and the AhR is an...

Abstract We examined the effect of a COVID-19 infection on changes in exercise levels in recreational athletes in the first three months after infection, and identified personal factors associated with a larger change in exercise level and recovery time. Recreational athletes (n=4360)...

In the 90s I improved up to 80-90% by doing nothing. I got worse after taking immune modulators and never returned to baseline. I shared this with my M.E doctor and he nodded his head.

Full Title: Not all roads lead to the immune system: The Genetic Basis of Multiple Sclerosis Severity Implicates Central Nervous System and Mitochondria Involvement, 2022, Vilija G. Jokubaitis et al Abstract Multiple sclerosis (MS) is a leading cause of neurological disability in adults...

Abstract Background The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis gut microbiota can contribute to disease, hence...

A bacterial driver of arthritis Autoantibodies can be detected in individuals at risk for developing rheumatoid arthritis (RA) before development of clinical disease. The source of these autoantibodies, however, remains unclear. Here, Chriswell et al. identified that IgG and IgA autoantibodies...

Abstract Orthostatic hypotension affects roughly 10% of individuals with hypertension and is associated with several adverse health outcomes, including dementia, cardiovascular disease, stroke, and death. Among adults with hypertension, orthostatic hypotension has also been shown to predict...

How PEM evolves over the years would also be a significant finding. My first PEM experience was very different during the five years of PVFS. Exercise and immune modulating meds relapse made PEM worse.

Some doctors still don't understand that depression is a physical illness.

I would need to put the drawing in translate too :laugh:

Ich kann kein Deutsch verstehen

@Wonko Did you get the flu and Covid shot at the same time? I'm considering getting both this time around.

Uncovering a connection between phosphate starvation signaling and mito membrane potential. Abstract Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a...

thread Thread on this Canadian Long covid clinic here: Canada: Edmonton Long covid clinic - Neeja Bakshi

Copied post thread

This was on the news here years ago.

Highlights • Six human mAbs target five distinct sites on EBV gH/gL • Some of these antigenic sites match sites of vulnerability on other herpesviruses • Each mAb neutralizes EBV infection and blocks virus-cell fusion • mAb 769B10 inhibits viremia and prevents lymphoma in an animal EBV...

A panel of investigational monoclonal antibodies (mAbs) targeting different sites of the Epstein-Barr virus (EBV) blocked infection when tested in human cells in a laboratory setting. Moreover, one of the experimental mAbs provided nearly complete protection against EBV infection and lymphoma...

My M.E onset was a sudden viral vertigo attack. I've had vertigo issues ever since (31 years). I think I might have contracted Covid a little over 2 years ago, it started with vestibular sickness and vertigo. I'm still dealing with this but it's seems to be resolving itself slowly...