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There are other scenarios, I fear, not the least of which is the infection - whatever it may be - persists by virtue of its own voracity and immune evasion capacity.

This is a sweeping claim.

Sometimes I feel sorry for these kids. They seem to be trying so hard. I think she used the word "self-compassion" somehow 17 times in just the title and 4 paragraphs above. That should count for something.

" Due to these factors, patients who satisfy the criteria for PTLDS may have had negative experiences in the healthcare field and experienced discrepancies between symptom onset and diagnosis. This may affect data in patients who may exaggerate symptoms to obtain care " Exaggerate symptoms...

This appears to have been authored by two individuals from a psychiatry department at a university in New Jersey. Writing about disease pathogenesis. Good grief.

To one degree or another, whether you're pro-vaccine or against, most feel swindled and lied to. Seems every other person is pissed. Science was supposed to be society's Great Arbiter, stoic and disinterested and fair, with medicine its compassionate side. Who with any long term illness...

I have a low regard for what they can infer from serum and CSF to begin with. Out of context, this can mean a few different things. I suppose it hinges - in part - on what they mean by "neutralized".

I can only access the abstract. Not sure what this quote is saying.

Add Covid to the growing list of pathogenic candidates behind MS. It's such a rare thing to see someone actually testing tissue, and brain tissue at that(!), for any neurological disease.

And profitable. Wouldn't want to ignore the Bayh-Doyle Act. Remember when academic research had the feel of being above smear, above the mercenary? Some people feel that may have changed a little back in 1980 with Bayh-Doyle.

Part of me is appreciative of the implication in "post-acute", although it's effectively muted by "syndrome". I'm curious, too, what sort of internal political dynamics might appear considering Yale's history in at least one area they'd be looking at. I hope they give Iwasaki free rein.

It buggers this bogged brain as to when and why medicine stopped assuming that when symptoms persist after acute stage, the pathogen was still mucking about somewhere in the patient. Isn't the way of infections typically acute and treat (if treatable)? Then either the patient's infection...

You're a good writer, @dave30th .

Hmm...Strle was an author. He was also an author of a similar study more than a decade ago, one with Steere. I am conflicted now. Is this another deflection? Focus on acute infections, maybe even a little disseminated, but decidedly no late stage? Do these more "dangerous" strains hold up as...

"To our knowledge, no large whole genome sequence (WGS) studies of human isolates have been conducted. Fewer than 50 human isolates analyzed by WGS have been publicly reported, either sporadically or included in cohorts consisting primarily of tick-derived isolates and in the majority of studies...

The study: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011243 Findings as summarized in Time: https://time.com/6310027/lyme-disease-genes-severe-disease/? My summary: How sick you get depends on the strain (vs species) of Lyme you're infected with. It's not a...

Late 60's through the early 80's was a very strange stretch, with some very peculiar and disabling diseases emerging. Certainly not keepsake days for the likes of the CDC and NHS. Makes one wonder what kind of water was going into what kind of cool aid.

Blunting immune responses theoretically can bring its own set of problems if there is an active - or reactivated - pathogen involved. This seems particularly relevant to LC if Covid persists in privileged sites, but also for lots of other things including ME/CFS and other neurological disorders...

I don't recall what UK is using these days. It used to be the C6. That's arguably worth a shot if you're covered for it. The US also used to use the C6. It was being positiioned to replace the 2T I think. But that didn't happen. Now there are the MTTT's, of which I think there are 4 different...

@Ash , yes it can and has. But that's a loaded topic on many levels. One of those is that Bb has been sometimes, albeit rarely, found in synovial fluid after treatment (rarely cultured even without treatment). Even when it's not cultured, many suspect Bb persisters are behind...