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Do we know if you can text in to LBC ahead of time? I have written a message because I wont be able to phone in. Otherwise I'll send it at 7pm sharp.

In a sane world it would be the other way around. You would rule out ME/CFS if you suspected depression.

Sums up the hypocrisy of the psychobehaviouralists pretty succinctly imo

I think if anyone's up to the task of recruiting that cohort it's the Edinburgh team.

Yes! Interested to know what the rationale was but I think side by side comparison of ME and LC like this could be very valuble.

The long covid aspect of SequenceME seems to be new since the announcement if I'm not mistaken?

How do we progess from where we are now to drug targets and treatment trials?

Does this have similar methodological issues to the other recent Moreau paper?

I have always been prone to both catching colds and getting infections in cuts and scrapes

Again, a lot like humans!

Some of these posts have been moved from the DecodeME preprint thread. Yeah LLMs are very good at confidently spouting bollocks.

Well the AI is really raining on my parade today! Lets hope its confidently incorrect on that front (not that I expect a drug tomorrow, nice as that would be...) It's weird though, I searched the preprint for drug, treatment and theraputic and only really found this phase claiming that the...

This is a very good point.

And, it seems, large meticulous genetic studies can be ignored also. Facinating what it's possible to ignore if your faith in the almighty psychobehavioral paradigm is strong enough. Almost inspiring.

Yes I think they are trying to hold back the tide by painting this study as much more insignificant than it is, saying 'well we are still light years away from having any idea what is causing this' etc...

Have we seen this gene before in ME/CFS research? Or am I just thinking of the Crawley pediatric LC study?

Drat. Hopefully F&M can raise the funds some other way then.

Understood. I certainly didn't think this gene was a definite slam dunk, just something that maybe strengthened the argument for JEs hypothesis. I hadn't realised that the IFNG/CD8 T CellI element was just from that one mouse model paper though. It would be interesting if we could come up with...

So, the 22 million kroner question is: do the DecodeME results strengthen the case for using Daratumumab?

It has a certain appeal! It sounds like something from an old sci fi film. This does all look rather relevant to your hypothesis, unless I'm very much mistaken?