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  1. InitialConditions

    Bisoprolol

    There's reasonably good evidence that propranolol improves symptoms of POTS, e.g., https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.846501, but I'm not sure its fully understood why. One theory is that excessive heart rates don't allow the heart to fill properly and so cardiac output...
  2. InitialConditions

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    What is the stats/maths behind this statement, please, i.e., where does the 150 come from?
  3. InitialConditions

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    Alan seems a touch angry, but I have to say, unless I am missing something, I am not really seeing the significance of this particular paper and its results, except for the fact some results have been replicated.
  4. InitialConditions

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    I have one reading, from a medical I had at the University of Leeds in 2014, before extended fieldwork. The value was 214 iu/L, which wasn't flagged because the stated normal range was given as 70–300 iu/L, but looking now this range seems wrong for an adult and my result is actually high.
  5. InitialConditions

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    There was a short section on Radio 4 this morning, at around 7.20am I think. Chris Ponting talking to Nick Robinson about this paper.
  6. InitialConditions

    Alternative to duvet for summer months

    Yep, this is why I've not looked for a throw/blanket, because they're often heavy, woven. Looking for something light and thin too.
  7. InitialConditions

    Alternative to duvet for summer months

    I did think about this. I think this is similar to what hotels do in warmer countries. Just a flat sheet to sleep under.
  8. InitialConditions

    Alternative to duvet for summer months

    Does anyone not use a duvet in hotter weather? If so, what do you use instead? I can't seem to find any clear alternatives. A flat sheet? Some sort of blanket? I don't really want to get a summer duvet as we're short on space.
  9. InitialConditions

    Submaximal 2-day cardiopulmonary exercise testing to assess exercise capacity and [PESE] in people with long COVID 2025 Thomas et al

    I've seen this elsewhere online with people stating that PEM is unique to ME/CFS whereas PESE is a more general feature of other conditions. However, scanning this paper, I'm not even sure that's what the authors are doing as they've not clearly stated that they are two different things, and in...
  10. InitialConditions

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    This is the 'fatigue psychologist' who wrote a critical response to the George Monbiot Guardian peice last October, then seemed to backtrack: https://www.theguardian.com/society/2024/oct/22/a-dualistic-view-of-illness-doesnt-help-those-with-me-cfs Edit: I've just seen that today he has a second...
  11. InitialConditions

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    Many of these people — including Liz Carlson, Lindsay Vine, Rebecca Kennedy — are RecoveryGrift™ YouTubers and social media folk, recycling the same patient stories that often sound like some form of burnout, and selling their own or each other's courses. I'm suprised Raelan Agle hasn't included...
  12. InitialConditions

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    Ok so probably his friends in Norway. I would do some sleuthing but it's been a while since I did any Wikipedia stuff. Can you see the other edits from this user?
  13. InitialConditions

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    Would this still apply given he's primarily a researcher/academic and doesn't practise medicine?
  14. InitialConditions

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    He's clearly been editing his Wikipedia page. This should be challenged if anyone is active on Wikipedia?
  15. InitialConditions

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    The person/people behind Long Covid Advocacy write quite well on BPS nonsense. There's sometimes a little too much "academic-speak" for my liking, but overall pretty good: https://www.longcovidadvoc.com/my-blog
  16. InitialConditions

    Open ReMEdi clinical trial, UK [Lindus Health, Alfred E. Tiefenbacher GmbH]

    I noticed yesterday that Dominic Cummings had a Lindus Health t-shirt on during a recent interview. I thought I recognised the name from somewhere.
  17. InitialConditions

    Ligaments and tendons

    I feel exactly the same. I have written about it here, I think. It's like my body cannot properly heal any injuries to soft tissue. I have issues that started 10–15 years ago that will not resolve. And, yes, any repetitive use makes things much worse. I have a problem with the soft tissue around...
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