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I'm imagining the same thing. If Decode recruits enough people to find something but falls short of its goal, there'd be a strong argument in favor of a GWAS drawing from a larger pool (perhaps USA or international).

Yes, generally.

They can't do that because their control group is UK residents. If they accept samples internationally, the control group's no longer a match.

Even if nobody else joins, I'd expect a GWAS of 9k people to still find something. In my non-scientist opinion.

I'm glad they're continuing to get research from the Rituximab cohort despite the drug itself not working.

*Squints closer* CSF Ah yes, the elusive disorder ME/CSF. Confusingly, the study also refers to CSF (cerebrospinal fluid) correctly.

There's no freaking way N95's are ineffective. It's basic physics and engineering; I'm not letting a meta-analysis with potential confounders confuse me. Anecdotally, many people in my social circle have had Covid 2-3 times already, I haven't had it once, and not for lack of going out.

I collect Childhood Disability Benefit--essentially a disability pension off a parent's work record--I lose my benefits permanently if I get married. Luckily I've never wanted to.

I feel pretty low whenever I buy food with food stamps. (For non-Americans: If you have low income, you get a card with money for food only. It was actual stamps long ago.) Nobody in the store knows I did everything right in life, then became disabled.

The paper's results are tantalizing is scant on details. For example, there's a correlation with climate but which direction? I laughed at their use of Plant Hardiness Zone--do they think we're flowers?--but it's interesting science.

I wish you and your team the best. It's estimated 250,000 people in the UK have ME, but how many actually have a diagnosis? We need to recruit a significant fraction of all people with diagnosed ME in the country, quite a hard task.

I'm also saddened by the turnout of only 9,000.

Familial dysautonomia is considered "functional"?!

How can you be a microphone if you refuse to listen?

Did he step out for a smoke? :)

Perhaps your family has a combination of genes that all contribute a small mount, hence no "smoking gun."

BPS researchers are bringing this up again?! I'm starting to feel like I'm reading a Reddit thread about politics, where people keep using the same canned arguments over and over.

Merged thread I want to see a study on vaccination as an ME treatment Let's pretend to be scientists. A subset of pwME (including myself) or LC have anecdotes of positive vaccine side effects. We could recruit only "responders" who've felt better after routine vaccination. Non-responders and...

I tried regular exercise and looking for the "right" way to manage my activities. Shockingly, it did nothing. Maybe I should've tried yoga instead hehe.

That's absurd. Biosocial discussion in other diseases is serious and useful, like, "Does poverty make it more difficult for you to afford medicine?" but in ME/LC it's garbage like, "Have you considered just not being sick lol" (Being satirical here)