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They also tested excluding purely psychiatric post-COVID cases, and the risk ratios were about the same. They also tested with minimum 8 weeks duration:

Retraction Watch: "A medical journal says the case reports it has published for 25 years are, in fact, fiction" Link

I feel represented. So great to hear some cool science knowledge from Dianna again with her characteristic overflowing excitement.

Ah okay. I assumed the non-specific Fukuda could easily hit a prevalence around 4x the prevalence with PEM. I see this one also gives a pretty high figure, but seems to also be based on questionnaires. Chronic fatigue syndrome prevalence is grossly overestimated using Oxford criteria compared...

This paper says abnormal P300 amplitude is consistent in fibromyalgia, though: Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: New trends and future directions (2006, Current Rheumatology Reports) Edit: Actually, it says abnormal P300 amplitude is consistent in...

Searching for P300 and ME/CFS, I found one about abnormal P300 in children with CFS (the last paper below), and normal P300 in three other studies. I don't think any required PEM. P300 assessment of chronic fatigue syndrome (1995, J Clin Neurophysiol) [Holmes 1988 and Schluederberg 1992...

Papers posted on S4ME that mention P300: Prefrontal dysfunction in post-COVID-19 hyposmia: an EEG/fNIRS study, 2023, Tommaso Longitudinal Exploration of Cortical Brain Activity in Cognitive Fog: An EEG Study in Patients with and without Anosmia, 2024, Gangemi et al. Neurophysiological and...

This paper is about individuals who were poisoned in a terrorist attack by the neurotoxin sarin in subways in Japan in 1995. Chronic symptoms after sarin exposure are interesting because there is some evidence that sarin may have been responsible for at least some cases of gulf war illness. [1]...

Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning Abstract To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in...

Are you referring to estimates for criteria which require PEM or compared to other studies of Fukuda? It seems plausible that prevalence would be much higher if PEM is not required.

This is based on Fukuda criteria:

Who receives a diagnostic label for fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome? A study in the lifelines cohort Tattan, Mais; Hanssen, Denise J.C.; Rosmalen, Judith G.M. Highlights • Only 25% with FM, 14% with CFS, and 48% with IBS received a formal diagnosis...

I should have mentioned this as well @tralfamadorian97. You might also be interested in studies of B cell receptor repertoires, which did find significant differences. It's not expanded clonotypes, but a specific gene was overexpressed on BCRs in both studies: IGHV3-30. Deep Sequencing of BCR...

Mesenchymal stromal cell therapy for post-COVID-19 syndrome: associated impact and mechanism Background Post-COVID-19 syndrome (PCS) affects around 10% of individuals who experience SARS-CoV-2 infection worldwide. This four-year follow-up study investigated the long-term impact of mesenchymal...

Some posts about Binita Kane have been moved to: Dr. Binita Kane - United Kingdom

You might be interested in this study on ME/CFS that did not find differences in T cell receptor repertoires: Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls, 2024, Dibble, Ponting et al

Don't you have to know what antibody you're looking for? Surely an assay can't contain every single human protein, so it doesn't seem like failing to find autoantibodies with these assays would be evidence that there aren't any clinically meaningful ones.

The blinding is interesting. Each patient received the placebo first, then the low dose at the next visit, then the high dose at the visit after that. The patients were unaware of this schedule, but the research personnel weren't.

It seems to me there should be a whirlwind of research following up on this. If low level sarin exposure from a war can lead to a chronic condition like GWI, and it has taken decades to unravel that association, how many other associations are there that we don't know about yet between sarin or...

It should be noted that there was a comment published which brought up a potential limitation of the study: there was no matching for ancestry between cases and controls, and thus the association between GWI and allele frequency, which varies with ancestry, may be due to ancestral confounding...