Exhaled breath-based clusters in children with post-COVID condition
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Background:
Pediatric post-COVID condition (PPCC) presents as a heterogeneous disease with a broad spectrum of symptoms. This study aimed to identify distinct phenotypes of PPCC through an unbiased...
Long COVID Does Not Impair Hemodynamic, Vascular, or Autonomic Responses to Maximal Exercise: Sex-Stratified Study in Young Adults
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Background/Objectives: Long COVID (LC) has been linked to fatigue, exercise intolerance, and autonomic dysfunction, but sex-stratified data...
Long COVID in the context of driving styles: An empirical study employing connected vehicle trajectory data
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Abstract
This manuscript examines the "long-COVID" phenomenon, defined for this study as lasting changes in driving behavior stemming from pandemic-induced travel...
I don't know if these are looking at exactly the same thing, but this other study seems to be the opposite:
Choroid plexus volume is enlarged in long COVID and associated with cognitive and brain changes, 2025, Diez-Cirarda et al
Maybe someone with access could see if they cited the older...
Choroid plexus alterations in long COVID and their associations with IL-6
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Abstract
SARS-CoV-2 disrupts the choroid plexus (ChP) epithelium by binding to the ACE-2 receptor, causing blood cerebrospinal fluid barrier leakage and permitting interleukin (IL)-6 and pathogens...
So they used a tool to identify pathways of interest based on levels of lipids in this cohort. The tool gives genes associated with the pathways as well.
The tool gave 25 genes that they could check the expression of using their previous RNA data, which I think was from the same cohort. 8 of...
Evaluating working memory functioning in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review and meta-analysis
Penson, Maddison; Kelly, Kate
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Abstract
Individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...
From the letter to the editor, with bolding added:
It's interesting that the authors think the most notable issue in a paper about developing a diagnostic test is that they didn't discuss alternative treatments.
And for the only example of such a treatment that they give, the only references...
Here's another resource explaining pseudoreplication, and they say it's likely usually researchers just being unaware it's an issue:
https://cambiotraining.github.io/stats-mixed-effects-models/materials/03-independence-pseudoreplication.html
Edit: Fixed link
Like another study from this group that was posted here, it looks like the p-values are artificially low due to pseudoreplication. I'll just quote the last time I said it, since it's the same issue, just with the sample size changed:
Now published:
Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events
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Abstract
How sleep maintains our healthy brain function has remained one of the biggest mysteries in neuroscience, medical settings, and...
A Psychobiological Approach to Gulf War Illness: Acute Exercise & DNA Methylation
Alexander E. Boruch
Thesis advisor: Dane B. Cook
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Background
Gulf War Illness (GWI) is a form of chronic multi-symptom illness characterized by medically unexplained and heterogenous symptoms...
Ideological bias in the production of research findings
Borjas, George J.; Breznau, Nate
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Abstract
When studying policy-relevant topics, researchers’ policy preferences may shape analytical decisions and results interpretations. Detecting this bias is challenging because...
So it turns out there's already a new version of the preprint that updated this sentence to say CSE1L instead of OLFM4.
It seems that something is wrong with the MedRxiv website, because it's not showing the "New Version Available" alert when I look at version 1. [Edit: They fixed the website.]...
You're right. I don't see any direct mentions of any specific criteria, except listed at the bottom as references.
Maybe it'd be good to include something about specific existing criteria. It might be helpful for people who are curious if their symptoms align with a more "official" source.
There are several criteria currently in use. I'm not totally sure what "consensus" criteria specifically means.
Fukuda (CDC 1994)
Canadian Consensus Criteria (CCC 2003)
International Consensus Criteria (ICC 2011)
Institute of Medicine (IOM 2015)
National Institute for Health and Care Excellence...
I think they named the wrong gene. OLFM4 isn't one of the 259 core genes in this paper's Extended Table 3, as far as I can tell. On the other hand, CSE1L is a DecodeME tier 1 gene that is one of this study's core genes.
And while DCC is one of the PrecisionLife core genes, it wasn't a tier 1 or...
I thought more about it, and came to the conclusion that this might be an inaccurate interpretation. Maybe it does add some confidence about the loci - seeing them come up again with a totally different method.
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