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I found this site useful with reviews of noise cancelling including of the QC Ultras

Do you mean because it’s a part of a subset of the immunoglobulin family it pops up or is there some other reason or link? I’d completely forgotten about the HLA-DQ find.

Not sure if this has been explicitly asked, but does the lack of MHC appearing to be significant in DecodeME results increase the likelihood of whatever is going on being MHC-independent. In other words, should we be looking more at something involving gamma delta T cells, MAIT cells, NK cells...

This would seem a straightforward way of finding out if it is NK cell count or some other factor that is important here. Limit the variables, use the same patients.

Thank you! That’s all really useful.

I don’t as I can’t get out anymore. But probably would if I could. The difference in people’s responses to someone who looks young and healthy but isn’t and someone who is older and looks frail but is fine is telling. People aren’t uncaring, I think, they just don’t know. How much the symbol is...

Thanks for the update @Utsikt It’s a shame they weren’t clearer over the funding, but who knows what uncertainties there have been behind the scenes and well, it’s fantastic they look likely to get all that is needed.

A bit more background on this can be found in this write-up, some quotes below

If you’d like to give a detailed explanation of what the mechanism is and why there is proof beyond doubt please do, I’m all for hearing it. I’m comfortable that I’m coming at all this from a place of ignorance and lack of experience, and find questions are a good way to learn.

Presumably this balance matters even for a particular cell type, like in the theory here? It’s not just ‘cell with this receptor gets killed’ it’s a probabilistic thing depending upon receptor makeup, how much daratumumab binds and other factors on deciding if a cell is killed? Separately to...

I’m a bit late to some of the detail of this paper but some questions I had which seem relevant to the current discussion When is the assumption made that ADCC and NK is important (Daratumumab seems to have other mechanisms of action)? Why is there an assumption of autoantibodies being...

Ah, yes, I couldn’t find that either. It says there’s an example in the supplementary materials but I can’t see it, only the results (in Table 1.xslx)

They used SF-36 Physical Function (SF-36 PF) and DePaul Questionnaire-Short Form (DSQ-SF). Is that what you need? Edit: was just about to post a better link but @Utsikt got there with the relevant text.

Got you. Sorry I’d misunderstood and assumed you meant before study completion and unblinding. My mistake and crossed wires with other posts. On recruitment, is it that or funding that would be the limiting factor here I wonder? I guess it’s difficult to know for sure.

How? This is in the study design (linked from the english fundraising page) It’s great there’s so much interest, hope and positivity about this trial. I know it’s hard but we should try to base discussion in what is known about the trial.

Sorry I’d missed that, good digging and thanks for the info.

Yeah, I think we’ve discussed this before, but getting appropriate basic support in place should be our focus I think. That’s not only badly needed but everything else including trials or treatments depends upon or builds on that. Yeah I’ve heard that can happen too, but what looks like the...

I’m not sure how we would know it’s a success until the trial is complete and unblinding occurs.

It looks like length of this study is 72 weeks per person, with staggered involvement (not everyone starting or finishing at the same time) and recruitment open from 06.06.2025 until 01.12.2026. So I wouldn’t expect results until later into 2028 at the earliest.

One of the documents attached to the english fund-raising page talks a lot about the mechanism and goal being reduction of autoantibodies, my understanding was this was not the case and it’s some other mechanism involving B cells/plasma cells, potentially antibodies but more autoimmune adjacent...