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I have never stopped thinking about this study and I keep an eye on any new research on UPR. I recently found this pre-print and contacted the senior author to see if he had any thoughts on me/cfs. Hwang's WASF3 paper found a disregulated pattern in the UPR proteins that you'd usually expect to...

I agree with this approach. Worrying about absolute p values isn't as important as ranking things and seeing if those things show up near the top in other studies. That's when there's actual signal. Another bit of info for anyone scrolling the mega list of correlates with severity, the acronym...

Couple of points @forestglip 1. I'm loving the embedded google sheets, that works really well for me. 2. I'm very impressed by your interrogation of the data and your commitment to extracting the true value from it. I notice you're not afraid to put in the effort. ;) 3. I believe Benjamini...

This is an unusual but deeply-researched paper, by leading biologists out of MIT in the US. Their work is beautifully explained by @SNT_gatchaman . If I understand it right they're proposing a whole new hypothesis for why oxidative stress can impair cellular function: simply by slowing the...

this is by Kathryn Melamed, now of UT Austin. She was publishing on me/cfs before covid, with systrom: https://www.s4me.info/threads/unexplained-exertional-intolerance-associated-with-impaired-systemic-oxygen-extraction-2019-by-melamed-systrom-et-al.11176/ This paper has impressive scale. It...

Me a few years ago, naive: Novel biomarkers, YES! Me now, jaded: novel biomarkers, UGH. Nobody ever follows up some random lab's weird expensive technique.

IN the long run I don't seem to be able to improve my exercise load, but in the short run, sometimes. I've at times increased how far I can walk, increased how much I can lift, increased how far I ride, etc. Later I crash and it all goes backwards. And its all gone backwards on net over the last...

Moved post I was looking for a good thread to put in some interesting recent progress I've made on IBS, and this one will have to do. I had been taking a certain probiotic on and off for the last few years but I think i've finally separated signal from noise and realised it si very effective...

An interesting matrix to explore with a survey might be I have POTS symptoms, am alcohol intolerant I have POTS symptoms, am NOT alcohol intolerant I have NO POTS symptoms, am alcohol intolerant I have NO POTS symptoms, am NOT alcohol intolerant

I would like to reiterate my original post: DOMS and PEM are different. DOMS is adaptive. PEM is pathological. DOMS is local. PEM is systemic. One is a system working. The other is a system failing. That doesn't mean they can't be using similar pathways. In one the pathway may be working, in...

Near the beginning of my me/cfs adventure, I was in what was essentially remission. I'd been sick really acutely for about 4 months, then suddenly and spontaneouly "recovered." I could exercise. Or I could go drinking. But the combination was a cause of PEM. I learned to separate alcohol and...

There are a couple of athletic phenomena that could share some similarities with ME/CFS. Over trainign syndrome is one: My understanding of this term is it refers to a long period of feeling weak, perhaps months or weeks of reduced performance that is alleviated only by rest. A sort of...

Salubrinal came to our attention via the Hwang study on WASF3. That study showed endoplasmic reticulum stress was causing WASF3 production and the WASF3 was screwing up energy production in the mitochondria by affecting supercomplex formation. (supercomplexes allow the mitochondrial membrane to...

I've encountered references to matrix metalloproteinaise a few times recently. https://en.wikipedia.org/wiki/MMP9 Its functions relate to the extracellular matrix, and [speculation follows] perhaps one reason science has struggled to find the answers to mecfs in the cell is that the issues are...

SHe replies: Glad to hear from you and thank you for your interest in the work (not a lot of it in this space, as you perhaps already know). Unfortunately, this is an abstract of the research I am presenting at a conference. The manuscript itself is submitted to a journal and we are waiting to...

My read of their other papers suggests the distinction is not that it is 3D printed, but that other researchers are using 2d layers of muscle cells, which don't fully capture the behaviour of muscles in certain conditions. They have these little slivers of 3d muscle and they seem to be able to...

There's a 2023 paper here that talks about the history and process behind "3D muscle models". Muscle-on-a-chip devices: a new era for in vitro modelling of muscular dystrophies Juan M. Fernández-Costa,1 Ainoa Tejedera-Vilafranca,1 Xiomara Fernández-Garibay,1 and Javier Ramón-Azcón1,2,*...

Is this a PEM model? we need so desperately to have a benchtop model in this disease. Working on people is so slow, expensive and variable. I didn't see this coming but I am excited by it. To be fair, "3-d in vitro skeletal muscle tissues" don't sound super cheap and easy to get! but they have...

Good to have this hypothesis formalised and published. I'm a little skeptical of how widespread this could be as an etiology of mecfs but perhaps it is a subset. To be clear the author, Bateman, is not well-known ME/CFS researcher Lucinda Bateman of Utah. It is instead two Batemans from NSW...

Small sample but they do also blend two other cohorts in and look for commonalities. This is not game-changing research or cure-finding research but it probably help tip the funding paradigm slightly in the direction of EBV and neuro issues. And when DecodeME comes out (suppposedly in August...