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I'm sharing this because it's an example of a metabolic issue with a barrier component. And involves STAT singalling, which I know the stanford people are investigating. It's also quite hopeful because they seem to be onto a fix with IL-22. The applicability of this to me/cfs is completely...

IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis Peng Zhang 1 , Junlai Liu 1 , Allen Lee 1 , Irene Tsaur 1 , Masafumi Ohira 1 , Vivian Duong 1 , Nicholas Vo 1 , Kosuke Watari 1 , Hua Su 1 , Ju Youn Kim 1 , Li Gu 1 , Mandy Zhu 1 , Shabnam...

I think sit / lie flat is an interesting dichotomy but legs up is a very important intermediate. I once had an office job where I wore a suit and I'd sit on my swivel chair cross-legged because it was the only way I could get through the day. (spoiler, by the end I could not get through the...

I'm always interested in any hypothesis with an adrenergic connection. beta blockers have been very useful for me, as has midodrine, an alpha agonist. I think vasomotor control by adrenergic receptors is part of the symptom set and we could certainly use upstream explanations of that. You note...

Berlin Cures will reveal the results of the BC007 Phase II trial in November at a Long Covid conference. https://www.berlincures.com/en/news/demystifying-long-covid-interntaional-conference-2024 "Dr. Oliver von Stein, CEO, and Dr. Axel Mescheder, CMO, will represent Berlin Cures at the event...

Excellent group of test subjects. I hope they have continued to follow up with them and seen how their health goes beyond 60 days. From 1170 covid infections you would probaby expect 400 to have some lasting symptoms at 3 months, maybe a third (130 ppl) of which is they can't smell or their...

You can see some level of self-selection in my response to the email from Baker institute: > thanks for the email. I'm probably going to hold off on this. My health has been retty tenuous recently and I can't afford a setback. I'll get in touch later in the year if I'm feeling more up to it...

Here's the PICF. It contains some language that will make some people concerned. And some stuff that looks good. The language some people might be concerned about: " It will also help inform people with ME/CFS what levels of activity might decrease the risk of PEM and guide doctors in designing...

I contacted them earlier in the year but then backed out of actually doing it as I was in a downward spiral at the time and worried about gettin worse. Here's the email they sent me. I think the research objective looks good and I should follow up with them! Hi , Thank you for completing the...

Pleased to hear this stands up because it's one of those things where I wasn't sure if it was folklore. I've heard it repeated a lot but also seen it questioned in these pages. A solid finding is a relief.

So just to clarify what you two are finding: there is a small difference between mecfs and healthy on a 2 day cpet ? Is that the top line?

I'm just hearing about paneth cells and they seem interesting. Here's two papers. First a background primer on how they maintain intestinal homeostasis. Those of us who seem to be in constant dysbiosis might wonder if our paneth cells are working properly. EMBO Mol Med. 2023 Feb; 15(2): e16427...

What was in common between Younger's video above and Cort's write-up is emphasis on the increased volume of research now (and increased number of researchers) and the collaborative approach. Younger says some good basic research will come out soon. I suspect his mention of subgroups is a way of...

This is a blogpost by an anatomy professor. I appreciate how he's not defensive about the fact that much is still to be known in medicine, rather he is excited and frustrated to get on with finding things out.

https://svpow.com/2024/09/07/were-not-going-to-run-out-of-new-anatomy-anytime-soon/ We’re not going to run out of new anatomy anytime soon September 7, 2024 If you are interested in making anatomical discoveries, good! Because relative to a single human life, the work to be done is...

I've just started reading this and there's a subtlety in it i appreciate. They distinguish exercise intolerance from PEM: Importantly, PEM is clinically often accompanied by fatigue and profound exercise intolerance. Yet, while being pathogenically connected, they constitute separate entities...

No difference visible in Hanson's four-timepoint metabolite study for 2-hydroxybutyrate, but a group difference for 2s-3r dihodroxybutyrate that kept increasing the more exercise the particpants did, until healthy control had more. The above chart taken from my interactive webapp that gives...

Stress granules are confusing. The only thing I know for sure is they need a rebrand, ought to be named something latinate and technical to get respect!

Phair and Davis are interested in the Jak-Stat inhibitor that de Meirlier uses, Filgotinib. They think it can turn off innate immune reactions and therefore address some of the fundamental issues in me/cfs. I admit I'm attracted to the idea that innate immunity is stuck on. It is plausible...

I'm always pleased to see scientists operate with open minds.