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Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome Vaishnavi Dandavate 1 , Nityanand Bolshette 1 , Rachel Van Drunen 1 , Gal Manella 1 , Hanna Bueno-Levy 2 , Mirie Zerbib 2 , Ippei Kawano 1 , Marina Golik 1 , Yaarit Adamovich 1...

One of the metabolic pathways we use, right at the start of actvity, is Phosphocreatine. It's used before the body can get normal metabolic pathways up and running, in the first 10 seconds or so. Isometimes wonder if we might rely on that for longer than other people and end up forcing levels...

it's not the sort of ultra cure you might hope for when matching a treatment to a defined subset. And with people whose course of illness is short, you'd expect some spontaneous remissions. Definitely ambiguous to me whether they have something there.

Well, 1. there's a lot of the body outside the mitochondria. most diseases find their cause other parts of the body. e.g. for us maybe the mitochondria are in themselves fine but they aren't getting enough substrate or oxygen or they keep gettign sent signals to fragment, or the cell itself...

Fascinating little paper. TTMV9 is an anellovirus. Wikipedia says: "Their virome has been present in most humans. They enter in the cell early in life and replicate persistently.[8] This happens in the first month of life. It remains debated whether or not the first infection is symptomatic...

I've noticed I react strongly to food made in a slow cooker. Even if the ingredients should be on my fodmap safe list. I now suspect that could be histamine intolerance! I wonder if this also explains why sometimes I can eat a tomato dish the day it's made but if it sits in the fridge overnight...

I've experienced hypoglycaemia related to rapid gastric emptying before. It usually follows a very specific pattern that is quite rare for me now I live a more constrained life. But it used to go like this: 1. eat not very much for hours. 2. eat a massive quantity of carbs. 3. start to do some...

I've had fodmap sensitivity for ages. I blew up one of those hydorgen breath tests and got a record score, suggesting my body wasn't coping well with them. But recently i've begun to suspect histamines. Keeping to the fodmap diet simply wasn't providing 100% effects. And even on keto I seemed to...

Fairly simple technique used. Pull out some PBMCs and run them through the Seahorse machine. Then create this BHI index based on the numbers it spits out. The findings appear significant between groups and also to distinguish severity levels. I wonder if it would be even more sensitive with...

I recently ran a self-experiment, reducing my beta-blocker dose for several weeks before reinstating it. The effect was noticeable within days. More beta-blocker: more capacity. I'm mild and have quite bad POTS and I strongly believe in a role for beta-receptors in my symptoms. I'm also on an...

It's an antibody, available to researchers. Quite expensive at $1486 for a milligram: https://www.antibodysystem.com/product/8926.html Perhaps one day everyone over 50 will be taking it each morning alongside their fish oil and celebrex and statins!

In the most excitable parts of the longevity research community they talk about "escape velocity". You live long enough to be there once the anti-ageing drugs begin accumulating fast enough that you don't die! It's not realistic, but there's a germ of truth to it, and you can see it in the...

I should add that not only are the benefits visible in mice engineered to be low in IL-11 but also in mice given anti-IL-11 therapy once they were already old.

Results here are pretty striking. Will be interesting to see how it pans out in humans if they try it for fibrotic lung disease. However the thing about ageing research in people is it takes a long time to collect data! Still I'm very excited about ageing research because it seems to...

2024 Jul 17. doi: 10.1038/s41586-024-07701-9. Online ahead of print. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan Anissa A Widjaja # 1 , Wei-Wen Lim # 2 3 , Sivakumar Viswanathan 2 , Sonia Chothani 2 , Ben Corden 3 4 , Cibi Mary Dasan 2 , Joyce Wei Ting...

Surprised that the very first iteration of the virus caused more long covid than the delta-era one, which if i recall correctly, caused more severe acute illness. But overall this matches my prior which is that as the virus mutates to cause less serious illness, there's a lower rate of long...

The alternative to publishing an n=1 study isn't usually an n=10 study, it's putting it in the file drawer so nobody ever hears about it. I welcome all data of all kinds and all sample sizes. Nobody sets out to do half-finished, under-populated, under-powered studies but logistics can get in...

For someone like me, my earning power is very much linked to how well I feel. I have very short-term projects that I can complete on a day I feel well. If I'm in a good period I can make good money. At other times weeks go by with no earnings.So my health shows up in my bank account. But that...

Simple but massive breakthrough to have a measurable correlate of OI. If you can measure it you can manage it.

So, this was an attempt to replicate two-day cpet with a really big sample and the differences persisted but don't look very big. Is that a fair summary? Is that why most of this thread is discussion of the inclusion criteria? People trying to explain why the differences don't look big? I...