Search results

So you think there's sufficient empirical evidence to disprove the concept of viral latency / viral reservoirs in tissue? What about John Chia's work?

I enjoyed the thread. There's definitely an emerging consensus among certain scientists in the US that there is a persistent pathogen (or pathogens). Do I think that's 100% likely to be true? No, the hit-and-run hypothesis is still plausible. Do I think it's a good clue worth digging into? 100%...

she is certainly keen to distinguish them. Especialy to the exteent that long covid cohorts include people who were hospitalised and have organ damage; and that me/cfs is not caused by coronaviruses (and maybe, just maybe, all prior mecfs is from one virus.) and that mecfs patients have been...

This is a highly ambitious paper. Big sample and some very sophisticated statistical analysis. I like it. This study is worth combining with all our other metabolomic studies to see what is consistent and what is not. It seems to find a role for gut microbes, and their products, espeically...

This thesis seems to be part of the evidence base for Hanson's swing to believing there's persistent infection. I observed a population of T cells that were positive for both CD4 and CD8 markers in both cohorts, as well as differences in the proportion of Tox+ cells within this population...

For those of us who haven't heard of neutrophil extracellular traps before: The Expanding Role of Extracellular Traps in Inflammation and Autoimmunity: The New Players in Casting Dark Webs Stephanie U-Shane Huang and Kim Maree O’Sullivan* James L. Stafford, Academic Editor Author information...

I just googled thesis embargos. They seem to imply something might be seeking publication or patenting. Which may be a hopeful sign.

> 81.80% sensitivity and 85.70% specificity That's decent. Although not the stark difference Stanford found: Although the thesis talks about a 1.5 hour hyperosmotic challenge and the chart above shows the separation is not as strong at 1.5hour as it is a bit later.

Strong paper. It provides further evidence for a fascinating observation in the disease; an observation that could suggest interventions. I'm pleased this avenue of enquiry is making progress.

Fascinating idea. Usually ideas out of China don't make much splash in the west but this paper is out of Tsinghua university which is China's #2 university, based in Beijing and their #1 tech/science university. Think MIT. So it is probably not junk science and could have some impact. The...

I'm quite taken by this paper. I like the way they've not just hunted for auto-antibodies but tried to see what effects those autoantibodies might have on tissues and whole organisms. I don't think they're claiming definitive proof that AABs are the cause of long covid, but they do provide a...

Supplementing with good quality coq10 makes a notable positive difference to me. Could be worth trying a different brand!

I'm feeling positive effects and taking shark oil, not sure about the from. Can't ascribe causation! Just generally have a higher pem threshold, can walk the dog a bit again. less ruined after the weekend (i have kids). The oil comes from "dogfish" that are caught for meat. The shark liver oil...

two month update: feel quite a bit better. Absolutely unable to confidently tell you if it's the shark liver oil. Lag is a real issue with identifying cause and effect because (1) lag makes it hard to avoid confounders creeping in while you wait for the effect to arrive, and (2) makes doing a...

Interesting!! One of the non-canonical causes of UPR (alluded to above) is a failure of calcium homeostasis in the endoplasmic reticulum. https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01062-y

Yes, hi ! Not currently but in my most mild periods this is how my mecfs used to remind me it was still lurking. I'd come home from a bike ride all sweaty and full of endorphins, carry on with my day like normal, go to bed, wake up and 24 hours later realise, oh no... The longer i've been sick...

This is such a weird quirk of the disease. If I cross some invisible threshold I get slammed later. It's a massive clue. I previously knew of only one bodily system with a delay built in - the development of antibodies to a novel pathogen. But recently I became aware of another - the end...

I'm always pleased when I see Whitney Dafoe posting online because it suggests he's feeling a bit better. His blog is chugging along recently and he keeps popping up on my instagram. He does seem to have had a big improvement then setback at some point recently because he registered a small...

:emoji_tea::emoji_tea::emoji_tea::emoji_tea::emoji_tea:

I just want to point out that these kind of -omics studies are still coming! Bergquist and Armstrong are going to drop a really detailed study soon, with LOADS of datapoints taken at 20 minute intervals and a couple of thousand metabolites and lipids. I'm keen to wrestle the existing data into a...