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I'm extremely excited by the WASF3 work by Hwang et al; so I can't help wondering about a possible link from their finding of endoplasmic reticulum stress to this finding of bigger lipid droplets. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation Jin-Sook Lee...

I really loved this article. I did a bunch of reading on how they developed the cure. It's worth understanding what pathways to success look like. 1. Success came when they stopped looking for a solution to the most upstream factor: the genetic defect. And started focussing on helping the...

I recently joined this forum and am posting links to some of the analysis I've done in recent years. One big piece of work relates to this Hanson study. I collected the data and put it online in a format that allows users to examine any metabolite...

Thanks for the kind feedback and intelligent questions. just the few mecfs studies I've looked at. I started this project expecting to find a great deal of agreement. One reason I fizzled out is that all I couldn't find much agreement. What's more despite the studies often measuring thousands...

A long time ago I compared the findings of this study to those of Germain, Hanson et al 2018. You can see the results below. Agreement between the two studies is moderate and that's a consistent feature of metabolomic studies. I hope to do more like this.

I agree with this take. The metabolome is very dynamic and highly individualised. Which means I think that a lot of metabolomic snapshots are less than useful. If there's no consistency in something then measuring it once is of dubious value. The that chart above is not the first time I've...

Related to peroxisomal function and a key product of the peroxisome, the plasmalogen: Having considered this paper on plasmalogen replacement therapy I've bought shark liver oil and started taking a couple of tablets a day. The product I got is this one...

Big picture: This was a challenging paper to write - difficult topic and difficult circumstances. It needed an exceptional scientist to guide it. Nath was not that scientist. He let down the mission of science by permitting this to be published in its current form. As the sample size receded...

This was a challenging paper to write - difficult topic and difficult circumstances. It needed an exceptional scientist to guide it. Nath was not that scientist. He let down the mission of science by permitting this to be published in its current form. As the sample size receded they needed to...

I think this is likely. Another possibility for some patients - and another reason the test might not be valid - is some might be aware of the history and when they see this easy/hard game come along, choose hard as much as they can with one eye on how the data might be intepreted !!

This does matter a lot. I consider it part of my #1 reason this test fails but you've made me realise it could be expressed more powerfully and directly.

I did a quick dig to see if their measurement of metabolites in cerebrospinal fluid lined up with a previous study on the same topic. I bring bad news. The folllowing plot is just a rough draft of the final analysis but it shows big disagreement. Many things Baraniuk 2021 found high, NIH found...

His strategy dominates everyone else's. Losing easy tasks is the simplest way to not dilute whatever hard tasks you've won (or those you hope to win later) ; in terms of prizes "in the basket". Winning easy tasks is an almost* pure bad strategy. Even if you're not sure if you can win a hard...

Good luck Daniel! Appreciate the attitude of not just doing the steps but making sure they matter.

Some screenshots from the game. Note that there's no clock ticking when you're filling up the bar so you don't know if you're going to make it. Here's how the bar looks before you fill it up. This is it about halfway full.

Ooh, you can play EEfRT on your own computer. https://www.millisecond.com/download/library/v6/effortexpenditureforrewardtask/effortexpenditureforrewardtask/effortexpenditureforrewardtask.web requires download and I am not guaranteeing it is virus free but I downloaded it and my computer still...

Got a reply from Treadway on EEfRT. He seems suitably cautious about the utility of using it in this population. Hi, Sorry for the delay. The task has not been specifically validated as a measure of fatigue. My understanding of the paper is that they are trying to understand the clinical...

I feel satisfied that I understand the test fails on 3 levels: 1. It is conceptually inappropriate to use in mecfs, a physical disease where effort preference isn't a legitmate scientific question, and in which the test hasn't been validated 2. The high failure rate of ME/CFS patients on hard...

1. My memory of this research program is they brought each patient in sequentially. Each person was at nih for around a week, one after another. (Which is why it took so long). Somebody way upthread was pondering this too but there's no way for subjects to speak to each other irl. 2. Because...

My reading is that the oil mostly comes from "dogfish" which is the shark they use for fish and chips. Apparently they're catching these fish anyway, they're pleased to be able to use the livers for something. What's more 25% of the weight of the shark is liver. Happily, dogfish is not...