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I do think better epidemiology might help; prospective studies. If you look at the history of AIDS and coeliac, figuring out who was getting the disease, where and when, was an important input to narrowing down the field of scientific enquiry. For example, one hypothesis I have is that...

Congrats to the University of Melbourne researchers ... and if you guys would like a further $22.50 to round that peculiar sum up, so nobody needs to say almost a million , or nearly one million, I will gladly donate!!

Here's another interesting review potentially showing some links from the UPR to systems we care about; cant fully vouch for this one, it's strictly for the diehards! Int J Mol Sci . 2026 Jan 27;27(3):1282. The Role of Crosstalk Between the Unfolded Protein Response and...

I found an interesting review paper discussing how the ER can control mitochondrial function via contact sites; it alludes to a mechanism of reducing mitochondrial activity after a certain period has elapsed (see my bolding in the abstract below). I thought that could possibly line up with...

To what extent were we previously aware that viral infection could cause changes to amino acids? I feel surprised to learn this. I threw the term "non coding amino acid" into PubMed, there's relatively few hits. Seaching "non-canonical amino acids" shows far more hits, but they are mostly...

Is this a joke at the expense of people who have mcas, or what?

@MelbME did some research that also suggested amino acid supplementation might help. An me doctor suggested it to me and I tried it. Did ti work? I thought at the time it helped. Should I trust that perspective? I didn't improve in an overall sense while I took it. but I was also exerting a lot...

That sounds kina like a guy whose academic career has drained him of the joy of discovery. He's focused on the pain of the process not the potential for patients. I know he recently moved university to sustain or get funding. Can't be easy. Hope he keeps trying. He hasn't thrilled me yet but...

I've shared this paper before, but one possible reason for changes in glycosylation is endoplasmic reticulum stress. ER stress causes a homeostatic response called the 'unfolded protein response' which has many effects, including, the paper says, changing the way glycans get added to proteins...

I encountered something like this in real life when a doctor tried to insist I should not nap. All the research, he argued, showed that people who don't nap feel less tired. I told him I would not be following that advice and a look of genuine distress crossed his face.

https://www.owlposting.com/p/mapping-the-off-target-effects-of This is great, an interesting essay on some very useful work. summary: Most pharma companies don't really care too much about discovering every off-target effect of whatever drug they are pushing through clinical trials. Why...

This chart should be data on the same cohort. A large majority of those on contraception scored over 100 and therefore must be in the ME group. If I'm reading this right, almost everyone they got in their study who was on contraception also had ME. (plenty of people with ME and not on...

If we were properly treated I don't think continuing to distrust physios would be a rational approach! They've always been good at treating people who are healthy just unfit. Problem is that's not us. In your scneario it would be though. That said I've had remissions and it's just not a hard...

Wust's colleagues have some preliminary data with some pretty striking separation between patients and controls. . Very hopeful line of research. Pleased it is happening in Europe rather than the USA given funding. With a bit of luck, money will continue to flow

the great thing about the POTS researchers, and the patients, and this company, and hopefully a few competitors, is they will chug along anyway and we can find out if your view was right.

Just thought this was an interesting one, you never see the medical establishment publish anything against exercise, but this study looks quite well-powered to draw the (limited) conclusions it draws..

Brain 2025 Jun 18: doi: 10.1093/brain/awaf235. Online ahead of print. Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis David O'Brien et al, University of Sheffield...

I think they are trying to make the arbitrary heart rate definition redundant! There's wide awareness that cerebral blood flow matters, it's just been a nightmare to measure via transcranial doppler. The HR change is thought to be secondary to the reduced flow, compensatory. The reduced flow is...

The more recent video that I shared includes a person with no dysautonomia diagnosis using the device and that person also shows blood flow to the head falling on standing. So the question of specifically what is different between POTS and non-POTS in terms of the read-out is not yet clear to...

I find the term unrefreshing completely unscientific and ambiguous. If I don't understand a word I try to break it down. Unrefreshing must be the opposite of refreshing. Refresh must be the process being described. What does that mean for a person? Should I feel "fresh"? Again? What would that...