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This is a detailed study on the proteomics of acute and sustained exercise in the healthy, it is paywalled but definitely the sort of paper that can help establish norms against which we can measure PwME. It also hints at a supplement that I'm about to check and see if we have any forum posts...

Here's another good chart from the thesis: Figure 21| ζ-potential (mV) of PBMCs versus time during incubation in hyperosmotic NaCl medium in |A| severe ME/CFS diagnosis donors (unchallenged black circles, NaCl blue triangles; n = 8) |C| mild/moderate ME/CFS diagnosis (unchallenged black...

There's another new video here from Lumia featuring POTS researcher Satish Raj. it's a bit scrappy, this video, they were tryig to integrate an experiment and an interview and it suffers from not seeming very smooth and professional. but nevertheless it is interesting. And in this thread a...

I consider myself mild and I'm amazingly fit for a person with ME; I'm more open to exercise's benefits than most, especially recumbent exercise. But .... 50 sit-ups and a minute of plank is the warm up!?!?! I just don't think you could find 12 overweight people who can do 200 situps in their...

Here's an older paper that I just found that reveals an interesting fact about UPR. It doesn't just work in the affected cell, it can transmit to other cells, which then begin the same UPR process. https://pmc.ncbi.nlm.nih.gov/articles/PMC11475223/ And guess what they think the mediators are...

I fear that maybe mendelian randomisation studies suck because it is cheap to do. You don't need any samples or pipettes, microscopes or a lab. You need nothing more than a database and a copy of some free stats software. Barriers to entry are low and so, even though the technique can be...

The r^2 on these looks good but the actual separation on the vertical axis ... isn't there. So the link with PEM is one to be wary of. I'm excited by ER stress and the link with Hwang's work but this is preliminary in my view. That said, EVs could be a really good place to hunt for UPR...

hmmm. Affinity for breakfast is a novel concept in medical literature. This is the sort of groundbreaking research we need. We should petition to get the name of this illness changed to breakfast affinity syndrome. [SARCASM TAG INCLUDED HERE FOR FEAR OF MISUNDERSTANDING !!]

Why's it always Chinese teams doing Mendelian randomisations? Did they just rediscover the technique? Mendelian randomisation must be okay right? It must be a legitimate technique? I am always suspicious because the very first one I read tested a link from long covid to mecfs and found none...

I agree the comparison is not apples with apples. Many differences. For further reference, the SF-36 from the unblinded phase 2 rituximab trial. means rose from ~40 to ~60 at 10 months. with very high dispersion. And this is the 2011 phase 1 trial. A bit hard to interpret but I think we're...

For comparison, some data from the placebo controlled rituximab trial. The Daratumuma sf-36 data ( from 25 to 55) look quite good compared to Rituximab (the centre chart below shows those getting the drug going from 35 to ~43 by 9 months) . Also in ritux the number of steps taken rose from...

Chris says in this video that he and Rob Phair will publish on the itaconate shunt later this year. Which will be interesting. Sounded more like hypothesis and explication of how it might work than big data, but perhaps I'm misreading that. He seems to be advancing the idea that if we are...

Sodium bicarbonate update! I think it is always worth documenting when you make a big mistake. here's my most recent. Last night I took way way more sodium bicarbonate than usual. several grams. maybe even 10g. this morning I have a migraine, which I've never had before. nausea and pain...

I should report my null results: didn't feel any different after trying bicarb soda. that's just once though. Will try again. I should also report my other reason for wanting to try this instead of a b-complex:: I had some blood tests and my b12 levels were too high, probably from taking this b...

I started taking some fizzy b-vitamins a while ago. I perceive a benefit over a short-tun time horizon, perhaps 1-4 hours. I've recently tried to be a lot more skeptical about what it is in any product that might be delivering the benefit. I had a good look at what they put in these tablets...

The things we know genes do map to diseases that have funding. Every gene with a study on it is an oncogene because cancer funding is wide and deep like the Pacific ocean! And as @jnmaciuch points out, every other gene appears to be a brain gene, because neurology has done a lot of work too.

I've been varying my diet recently. I find sugar has wonderful short run effects, I think it changes some things for the better, not just readily available energy but also maybe blood pressure. However periods I can manage to cut it out are periods where my PEM is far less. Sugar is a real...

This is great. Do I have a guess what "flux" will be? Na.

Another new paper with a lot of features that seem relevant to Hwang's finding: UPR, Tudca, extracellular matrix, fibronectin: Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation An interesting finding is that disturbed turbulent blood flow creates...

I think the Lumia device that they have started marketing to people with POTS in the US is a chance of giving this data in a really useful format. it measures blood flow to the ear, which is (they argue and have data to show) a good proxy for blood flow to the brain. Now, this proxy relationship...