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Should you filter for low p values before running your correlation? if the studies truly correspond you'd find lots of things measured at 1:1 in both studies, there will be a cloud around the centre of the plot and it won't affect your r^2. I think running the correlation on the full dataset is...

There's a reference to photo-staining t-cells from fat and then finding them in the brain. I think. Is this paper saying t-cells are travelling from the fat to the brain?

This is a good warning. I've taken to buying some of my more expensive supplements from Aliexpress, which is even riskier! (Ubiquinol is sooo expensive!) I should probably stop doing that.

I've just read the paper and I'd like to praise the writing in it. Clear and accessible, chatty but somehow still formal, it's a rare treat to encounter something so well put together.

This is a really good point - AI keeps changing. I see people saying things about it that were true a few months ago, e.g. "it can't even draw fingers!" that are simply not true any more. If you take a principled stand against AI and stop using it (which is probably a good idea!), you don't...

um, you know what, i think maybe it was benjamini hochberg. yep, they mention that. I mis-remembered.

While we are talking about statistical intuitions, I find adjustment for multiple comparison to feel very weird. You take a bunch of p-values and just multiply them by a big number. It's effective at making lots of possibly significant results go away. Lot of bathwater gets thrown out and an...

I share this piece because I suspect some researchers are getting excited by AI. I don't think it's anywhere near being generally useful yet. Of course there might be tasks where it can be deployed really usefully. In my own line of work it is incredibly useful at transcribing audio, for...

https://www.understandingai.org/p/i-got-fooled-by-ai-for-science-hypeheres I got fooled by AI-for-science hype—here's what it taught me I used AI in my plasma physics research and it didn’t go the way I expected. Nick McGreivy May 19, 2025 In 2018, as a second-year PhD student at Princeton...

Montreal Cognitive Assessment = MoCA. 54 patients, 30 controls. I'm feeling the post covid brain slump myself. I usually do a few word games before bed and after having covid a couple of months ago I'm not doing well at them!

If we did do this we should specify in advance what the intent is? Perhaps it could have three sub-goals: 1. determine feasibility of self-capillaroscopy. 2. get a rough feel for the extent of peculiar looking capillaries in a self-selecting, unblinded pwme population. (is there an ai you can...

Here's my beginner attempt, just as proof of concept before I try to improve: Methods: one human pinky finger, one digital microscope, one dab of oil (canola!), one smartphone to take a photo of the digital microscope screen, one assistant to hold the microscope stable while I used the...

This looks interesting: muscle fibre types. If we look at panel C we have pre and post bed rest (pre is white, post is grey). There's not much movement in the four fibre types. rest doesn't seem to change their composition. But in the final chart of panel B we see controls, long covid (red) and...

Those are standard error bars not standard deviation bars. sd tells you about variation in the sample, se tells you about variation if you drew a bunch of samples from your sample. Those graphs are clearly made in excel and I believe excel does standard error as the default!

Yes, diabetes has microvascular abnormalities visible on capillaroscopy. Apparently diabetes includes a lot of "connected" vessels, which reminds me of the idea of "shunting" which David Systrom has raised. So it is unlikely this test would reveal patterns unique to me/cfs. What it might do...

for anyone else who also doesn't know Tom: Tom20 is a protein that plays a crucial role in mitochondrial protein import. It's a receptor on the outer mitochondrial membrane that recognizes and binds to mitochondrial precursor proteins with a presequence, facilitating their translocation across...

Ankush Dehlia has a review paper published with Mark Guthridge (thread, abstract below). Guthridge is not actually the researcher to whom the TCR funding went. (That's Ken Walder, who is at a different Deakin campus). Perhaps Dehlia is working with Walder but they simply didn't co-author the...

Cerebral flow is probably the core issue in POTS and without measuring that you're measuring compensatory effects. Arguably the HR boost is the body trying to get blood to the head.

This looks like a really easy test, they push a microscope against the bit of skin where it joins onto the fingernail and take photos of the capillaries https://www.sciencedirect.com/science/article/pii/S1521694223000359 Would be great to have this test tacked onto any future metabolomic /...

I'm always interested to see theories where LPS can trigger PEM-like symptoms. I have poor digestion and often digestive disturbances can leave me exhausted and very brainfogged. I've come to think of that as leaky gut pushing LPS into the blood. Duration is usually not as bad as PEM from...