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  1. V.R.T.

    Open [USA] A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID [ADDRESS-LC]

    So this reports in like 6 months! I'd forgotten about it tbh, and how fast they're moving. So it works on TLR pathways, not clear which from this - could be interesting to know if this has an effect.
  2. V.R.T.

    Autoimmune Disease is Associated with Heightened Long COVID Risk but Prior Immunization is Protective, 2026, Malakooti et al

    Does this tell us anything interesting?
  3. V.R.T.

    SequenceME genetic study - from Oxford Nanopore Technologies, the University of Edinburgh and Action for ME

    Do we have estimations of how long SequenceME and Long Covid will take? I think someone estimated 18 months when it was first announced but that was when it was just going to be the analysis of DecodeME samples iirc. Obviously the LC collection phase will take longer. If the project is...
  4. V.R.T.

    USA: Mount Sinai PACS clinic and Dr David Putrino

    Why is it that people who flog poorly evidenced treatments always go on about there not being magic bullets, like that makes their poorly evidenced treatment more appealing?
  5. V.R.T.

    Needing to lie flat

    Also when you're severe ignoring that urge can lead to absolutely brutal crashes.
  6. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I maintain that pilot trials should have controls, even if that isn't 'how its done'. I think there would be less failed phase 2s if they did.
  7. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    The responses in the ritux pilot do not look like the dara ones - someone posted them in one of these threads the other day. They are not anything like as sustained or as large. In phase 2 ritux failed in its primary outcomes but they went ahead because of secondary stuff iirc. I'm not saying...
  8. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I think we could debate this til the cows come home but I disagree.
  9. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I mean that F&M should have included controls in the pilot. If none of the controls had had sustained improvements like the improvers who got the drug did, we could be a good deal more confident that the results are not placebo.
  10. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Can you say anything about any more targeted projects you're aware of? All I can think of is the CA10 investigations that JEs pain colleagues are setting up.
  11. V.R.T.

    Multi-omics identifies lipid accumulation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cell lines: a case-control study, 2026, Missailidis et

    Exciting that you are uncovering other avenues! Are any of those projects written up/submitted or are they still ongoing?
  12. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I think this should be standard. If F&M had done this with dara we'd be much further on by now.
  13. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    And that's also why I have so much hope riding on the dara trial, try as I might to not put too much hope into it
  14. V.R.T.

    Researchers looking specifically at PEM?

    I think @MelbME is doing a good day/bad day study? And @jnmaciuch has mentioned wanting to do a study where blood draws are done on patients currently in PEM. Apologies if I've got either of these wrong.
  15. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I think they are being told porkies by esteemed personages with vested interests.
  16. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Yeah I remember isa maybe being better at depleting cd38 than dara or something? I can't remember, no spoons to look it up but I saved it somewhere. It would be a real turn up for the books if cd19 works. I'm glad CS seems to be moving swiftly with those trials.
  17. V.R.T.

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    How would this be done?
  18. V.R.T.

    A thread on what people with ME/CFS need in the way of service

    I agree, this is odd. i suppose there are 2 LDN trials on going, one of which is testing pyridostigmine as well. But you would have thought if they're happy to give them to patients they would be pushing for formal trials...
  19. V.R.T.

    A thread on what people with ME/CFS need in the way of service

    Why did nobody make a case for Daratumumab or did this happen before the pilot was out?
  20. V.R.T.

    Is there a connection between ME/CFS and Sjogren's Syndrome? Discussion and a poll about testing

    Yeah a survival of the fittest/exercise worship culture has infiltrated every aspect of our lives and medicine is no exception
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