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Link to the article: https://mecfsscience.org/immune-findings-in-me-cfs/

This could align with the Dutch autopsy reports. Correa da Silva described the findings as follows: "So in the patients that donate their brains, possibly endstage patients, we do not see signs of classical neuro-inflammation, but we see dystrophic, rather senescent microglia .... ME/CFS has...

I think this would show as less fibre fraction (NII-FF) while this measure was increased in ME/CFS. More water in axons or less water outside it seem like the two most plausible explanations but not sure what this might mean in terms of pathology.

There are two lines of dicussions. One is about the statistics. We find it weird that there were more significant findings when confounders like age, sex, depression, anxiety were added to the model. It's possible that this happens but usually adding confounders like this will result in less...

I'm not that good at math but I think the very free water (with diffusion > 2.5 μm2/ms) doesn't even enter their equation. The second part represents the isotropic components, an integral from a to b where "a and b are the low and high diffusivity limits for the isotropic diffusion spectrum...

My guess is that signs of edema would show up as an increase in the isotropic hindered fraction (0.3.<D≤2.5μm2/ms). But in ME/CFS this was decreased instead of increased. As Hutan explained, the same goes for the isometric restricted fraction (D≤0.3μm2/ms). This is water that could go any...

To add to the confusion the obesity paper defined the 'DBSI-hindered fraction' as > 0.3 µm2/ms; Source: Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging - PubMed So as @ScoutB already highlighted, why does the current ME/CFS paper put the...

Still confused about what the hindered fraction means and how it relates to edema. Some papers describe it as follows: Source: "A new imaging modality to non-invasively assess multiple sclerosis pathology" - PubMed The current ME/CFS paper defines it as: But other papers described a similar...

Suspect they did this to rule out that comorbid anxiety or depression were driving the effect. Bit of a longshot but perhaps the increase of significant results after controlling for potential confounders was due to anxiety/depression having an opposite effect to ME/CFS? Or (also speculative)...

Thought this was a third measure which they refer to as: "fibre fraction (NII-FF, indicating apparent axonal density)"

The Dutch autopsy study found none: Agree, but it does increase the risk of p-hacking because you can introduce several other variables into your model to see whether they lower the p-values. Same with this decision. This might be reasonable, but it also creates an opportunity to present...

Thanks Hutan and ScoutB, I was running into the same issues. Here's how I understand it: hindered water ratio (NII-HR) indicates places were water is very free to diffuse while restricted fraction (NII-RF) are places where water is very restricted to diffuse. In inflammation both measures are...

Looks like an application of AI in medicine that could actually be useful. The paper was published in Cell: Multimodal AI generates virtual population for tumor microenvironment modeling: Cell

'The convergence of digital transformation and the GenAI revolution creates an unprecedented opportunity for accelerating progress in precision health. Precision immunotherapy is a poster child for this transformation. Emerging technologies such as multiplex immunofluorescence (mIF) can assess...

Some comments I made myself: 1) New Polybio study reports: "We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested." So while RNA and proteins from the virus were present, these were found in controls as well. 2) The...

Some critical comments by immunologist Mark Veldhoen: https://bsky.app/profile/marcveld.bsky.social/post/3mgyxka7w3z2n

Some critical comments by Data Sleuth Sholto David

Here's what I got for tryptase-related genes on chromosome 16 (using GRCh38) And using locuszoom: Looks like my own code doesn't pick up on IGHE (position: chr14:105,597,691-105,601,728) for some reason but here's the data around that position. And here's the location on locuszoom with...

There were no signals at the p < 10^-6 level on chromosome 14 or 16.

Oxaloacetate is also listed with no mention of the conflicts of interest of the people who conducted these trials.