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  1. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    I recently was interested in migraine because I found a large correlation using Google Trends scores, showing that [edit: US] states that search more for "chronic fatigue syndrome" tend to also search more for "migraine" and "migraine aura". I previously also did genetic correlations using...
  2. forestglip

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    I'm wondering about the specific points Hutan raised that don't seem to have been addressed yet. Is this study concluding that lipids are a problem in ME/CFS based on comparing an ME/CFS group that could potentially include individuals with multiple comorbidities to groups where individuals...
  3. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-acute infection syndromes (PAIS) are multisystem disorders involving immune, vascular, neuroinflammatory...
  4. forestglip

    News from Germany

    You can copy the website URL into https://translate.google.com/?sl=auto&tl=en&op=websites and it'll translate the whole page. Or just copy bits of text to translate. If you use Firefox browser, it also has built-in translation, explained here...
  5. forestglip

    Preprint Risk of Post-acute Symptoms and Conditions After SARS-CoV-2 Compared to Other [Resp. Viruses]: A Systematic Review and Meta-Analysis, 2026, Pinto+

    Risk of Post-acute Symptoms and Conditions After SARS-CoV-2 Compared to Other Respiratory Viral Infections: A Systematic Review and Meta-Analysis Background How post-COVID-19 condition (PCC) differs from post-acute infection syndromes (PAIS) caused by other respiratory viruses remains...
  6. forestglip

    Preprint Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in [CFS] and Long COVID, 2026, Petrov, Maes et al

    Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in Chronic Fatigue Syndrome and Long COVID Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are complex chronic conditions that often follow infectious...
  7. forestglip

    Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials, 2025, Chang Tan et al

    Corrigendum to ‘Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials’ [Line breaks added] Description of the error and impact on results and conclusion After the publication of this article, a post-publication review revealed that, due to an...
  8. forestglip

    Review Effects of Exercise-Based Pulmonary Rehabilitation in Patients with Long COVID: A Systematic Review and Meta-Analysis, 2026, Silveira et al

    Effects of Exercise-Based Pulmonary Rehabilitation in Patients with Long COVID: A Systematic Review and Meta-Analysis Background/Objective A substantial proportion of infected individuals develop persistent symptoms after the acute phase of COVID-19, regardless of initial disease severity...
  9. forestglip

    News from the USA, United States of America

    Press Release: "Stealth Adapted Viruses Contributing to the Increasing Incidence of Colon Cancers: An Urgent Call for Extended Viral Studies" Snippets:
  10. forestglip

    Preprint Shear Stress Tolerance Threshold, eNOS Uncoupling, and the Two-Threshold Model of [PEM] in [LC]: A Mechanistic Hypothesis [...], 2026, Karipidis et al

    Shear Stress Tolerance Threshold, eNOS Uncoupling, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis with Implications for Physiotherapy Practice Karipidis, Yiannis K.; Karipidis, Konstantinos Y. Background A subset of Long COVID patients presents...
  11. forestglip

    Cardiopulmonary Exercise Test Results Do Not Change Over Two Sequential Days in Patients with Chronic Fatigue Syndrome, 2026, Mancini, Natelson et al

    Cardiopulmonary Exercise Test Results Do Not Change Over Two Sequential Days in Patients with Chronic Fatigue Syndrome Background Two consecutive cardiopulmonary exercise tests (CPETs) performed 24 hours apart is increasingly used to determine post-exertional malaise (PEM) and disability in...
  12. forestglip

    A crumb of a clue on epidemiology

    Yeah, they put the statistics about Hispanic characteristics in other tables. B03001 has the number of Hispanic people in each state, as well as specific countries of origin. I hadn't realized that other table was there, so thanks for bringing this up.
  13. forestglip

    A crumb of a clue on epidemiology

    Just looking at these maps of median housing age in US states or counties, it doesn't seem to match up well with the map of ME/CFS searches: ME/CFS search interest: Is there a better variable for the old house hypothesis? And please keep the ideas coming, whether or not they're fully baked.
  14. forestglip

    Trial Report Aminopeptides ameliorate long COVID symptoms in immunocompromised rheumatic patients through immune reconstitution, 2026, Shi et al

    Aminopeptides ameliorate long COVID symptoms in immunocompromised rheumatic patients through immune reconstitution Objective To evaluate the effects of aminopeptide nutritional support on immune reconstitution and antiviral capacity in immunocompromised patients with rheumatic diseases...
  15. forestglip

    A crumb of a clue on epidemiology

    I think maybe your research work is trying to do something different. If it's something like identifying what gene transcripts are important, and two genes are highly correlated due to being part of the same pathway, then it makes sense to just try to identify a single marker of that pathway...
  16. forestglip

    A crumb of a clue on epidemiology

    Just visually looking at fitted values vs residuals, with a univariate model for each of the four variables, it doesn't look like any huge departures from linearity. Some outliers that might be skewing the slope. Maybe not the cleanest line for Welsh. Here's the raw Welsh proportion plotted...
  17. forestglip

    A crumb of a clue on epidemiology

    For migraine, the very high correlation I saw with "chronic fatigue syndrome" was with the search term "migraine aura". "Migraine symptoms" is also high, just not as high. In terms of sex bias, Wikipedia says that migraine without aura is where there is a significantly larger risk in females...
  18. forestglip

    A crumb of a clue on epidemiology

    One thing I was thinking about is that all the British and Irish ancestries probably tend to be in the same states, so, for example, is Welsh correlated with ME/CFS searches just because Scottish is, with the same states having high populations of both? I tried doing a regression with all of...
  19. forestglip

    A crumb of a clue on epidemiology

    I'm not sure if this is what you mean, but I previously tested all ancestries' correlations with ME/CFS search interest: https://www.s4me.info/threads/a-crumb-of-a-clue-on-epidemiology.49455/post-683712 It seems that proportion reporting Scandinavian, Swedish, Norwegian, or German are all a lot...
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