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  1. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Note that we also have this migraine-related thread: Migraines and ME/CFS - Thread for sharing experiences
  2. forestglip

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    Small correction that one group, hypertension, had a higher median BMI.
  3. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Interesting! Maybe another similarity, from Wikipedia: A paper discussing whether ME/CFS might improve during pregnancy: Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years (Journal of Midwifery & Women's Health, 2008) There's a...
  4. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Not just one statistic. One p-value for every one of the millions of genetic locations that were tested in the GWAS, based on how often there was a variant at that location in ME/CFS versus the controls. The summary stats are often publicly available, including for DecodeME. There are a few...
  5. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    No, it is comparing GWAS summary stats from two different conditions. For example, the DecodeME summary stats give us an idea of how much each variant is associated with ME/CFS on a population level. They obtained summary stats for migraine and several other conditions as well, and compared each...
  6. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Genetic correlations are basically showing how similar the genetic influences are for two traits. If completely different variants were associated with ME/CFS compared to migraine, then the genetic correlation would be 0. If the exact same variants were associated in the same direction with...
  7. forestglip

    Comparing ME/CFS following mononucleosis with Long COVID, 2026, Jason et al

    Comparing ME/CFS following mononucleosis with Long COVID Jason, Leonard A; Furst, Jacob; Katz, Ben Z Objectives Long COVID following SARS-CoV-2 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) following infectious mononucleosis (IM) are examples of post-infectious chronic...
  8. forestglip

    Preprint How Revolving Door Officials Shaped, Cross Validated and Closed [..] Chemical Exposure Determination Despite the Evidence, 1995-2002, 2026, Ford [GWI]

    How Revolving Door Officials Shaped, Cross Validated and Closed the Official Khamisiyah Chemical Exposure Determination Despite the Evidence, 1995-2002 Ford, Jeffrey S Abstract The official Khamisiyah chemical exposure determination was presented as a scientific conclusion reached through...
  9. forestglip

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    I guess I don't see why not. Maybe I'm not understanding something about the methods. There will probably be a portion of migraine sufferers, or asthma sufferers, who have type 2 diabetes or any of dozens of other conditions, just due to some people having more than one condition due to random...
  10. forestglip

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    From the sensitivty analysis paragraph: Is this saying an ME/CFS group was created which excluded only those 7 conditions, and compared that group to C2? So could the ME/CFS group still have included individuals with type 2 diabetes or other conditions? I guess the concern could be put simply...
  11. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    I recently was interested in migraine because I found a large correlation using Google Trends scores, showing that [edit: US] states that search more for "chronic fatigue syndrome" tend to also search more for "migraine" and "migraine aura". I previously also did genetic correlations using...
  12. forestglip

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    I'm wondering about the specific points Hutan raised that don't seem to have been addressed yet. Is this study concluding that lipids are a problem in ME/CFS based on comparing an ME/CFS group that could potentially include individuals with multiple comorbidities to groups where individuals...
  13. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-acute infection syndromes (PAIS) are multisystem disorders involving immune, vascular, neuroinflammatory...
  14. forestglip

    News from Germany

    You can copy the website URL into https://translate.google.com/?sl=auto&tl=en&op=websites and it'll translate the whole page. Or just copy bits of text to translate. If you use Firefox browser, it also has built-in translation, explained here...
  15. forestglip

    Preprint Risk of Post-acute Symptoms and Conditions After SARS-CoV-2 Compared to Other [Resp. Viruses]: A Systematic Review and Meta-Analysis, 2026, Pinto+

    Risk of Post-acute Symptoms and Conditions After SARS-CoV-2 Compared to Other Respiratory Viral Infections: A Systematic Review and Meta-Analysis Background How post-COVID-19 condition (PCC) differs from post-acute infection syndromes (PAIS) caused by other respiratory viruses remains...
  16. forestglip

    Preprint Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in [CFS] and Long COVID, 2026, Petrov, Maes et al

    Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in Chronic Fatigue Syndrome and Long COVID Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are complex chronic conditions that often follow infectious...
  17. forestglip

    Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials, 2025, Chang Tan et al

    Corrigendum to ‘Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials’ [Line breaks added] Description of the error and impact on results and conclusion After the publication of this article, a post-publication review revealed that, due to an...
  18. forestglip

    Review Effects of Exercise-Based Pulmonary Rehabilitation in Patients with Long COVID: A Systematic Review and Meta-Analysis, 2026, Silveira et al

    Effects of Exercise-Based Pulmonary Rehabilitation in Patients with Long COVID: A Systematic Review and Meta-Analysis Background/Objective A substantial proportion of infected individuals develop persistent symptoms after the acute phase of COVID-19, regardless of initial disease severity...
  19. forestglip

    News from the USA, United States of America

    Press Release: "Stealth Adapted Viruses Contributing to the Increasing Incidence of Colon Cancers: An Urgent Call for Extended Viral Studies" Snippets:
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