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Shear Stress Tolerance Threshold, eNOS Uncoupling, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis with Implications for Physiotherapy Practice Karipidis, Yiannis K.; Karipidis, Konstantinos Y. Background A subset of Long COVID patients presents...

Cardiopulmonary Exercise Test Results Do Not Change Over Two Sequential Days in Patients with Chronic Fatigue Syndrome Background Two consecutive cardiopulmonary exercise tests (CPETs) performed 24 hours apart is increasingly used to determine post-exertional malaise (PEM) and disability in...

Yeah, they put the statistics about Hispanic characteristics in other tables. B03001 has the number of Hispanic people in each state, as well as specific countries of origin. I hadn't realized that other table was there, so thanks for bringing this up.

Just looking at these maps of median housing age in US states or counties, it doesn't seem to match up well with the map of ME/CFS searches: ME/CFS search interest: Is there a better variable for the old house hypothesis? And please keep the ideas coming, whether or not they're fully baked.

Aminopeptides ameliorate long COVID symptoms in immunocompromised rheumatic patients through immune reconstitution Objective To evaluate the effects of aminopeptide nutritional support on immune reconstitution and antiviral capacity in immunocompromised patients with rheumatic diseases...

I think maybe your research work is trying to do something different. If it's something like identifying what gene transcripts are important, and two genes are highly correlated due to being part of the same pathway, then it makes sense to just try to identify a single marker of that pathway...

Just visually looking at fitted values vs residuals, with a univariate model for each of the four variables, it doesn't look like any huge departures from linearity. Some outliers that might be skewing the slope. Maybe not the cleanest line for Welsh. Here's the raw Welsh proportion plotted...

For migraine, the very high correlation I saw with "chronic fatigue syndrome" was with the search term "migraine aura". "Migraine symptoms" is also high, just not as high. In terms of sex bias, Wikipedia says that migraine without aura is where there is a significantly larger risk in females...

One thing I was thinking about is that all the British and Irish ancestries probably tend to be in the same states, so, for example, is Welsh correlated with ME/CFS searches just because Scottish is, with the same states having high populations of both? I tried doing a regression with all of...

I'm not sure if this is what you mean, but I previously tested all ancestries' correlations with ME/CFS search interest: https://www.s4me.info/threads/a-crumb-of-a-clue-on-epidemiology.49455/post-683712 It seems that proportion reporting Scandinavian, Swedish, Norwegian, or German are all a lot...

Why does FND mainly affect women? A consideration of gender imbalance in neuropsychiatric disease [Line breaks added] Background Functional neurological disorder (FND) is a common and disabling neuropsychiatric condition in which women comprise approximately 75% of cases. This paper...

Pathophysiological mechanisms of post-exertional malaise: an integrative analysis based on the metabolism-immune-neuro interaction model Abstract Post-exertional malaise (PEM) is a common core symptom in various chronic debilitating conditions, such as Post COVID-19 Condition (PCC, also known...

There seem to be a few main possibilities that all seem plausible: People with British or Irish ancestry have a higher genetic predisposition to ME/CFS. States with higher British or Irish ancestry have higher levels of an environmental risk factor for ME/CFS (e.g. infections). People with...

I was talking about the British - ME/CFS correlation with my brother, and he said something like "aren't those basically the states that have the most white people?" and suggested that it could be basically how white people may get diagnosed at different rates from other races due to cultural...

Should we be thinking more about migraines? Autoimmune disease is often discussed as also having a similar sex bias to ME/CFS. But migraine fits that picture as well, and does not really seem to be in the same category as autoimmunity. The large scale correlation search with other trends scores...

Association of ADIPOQ rs1501299 with long-COVID syndrome: a single-center cross-sectional study Background Long-COVID syndrome is a public health issue, affecting millions of individuals worldwide. However, the pathophysiological mechanisms underlying the syndrome’s sequelae are still under...

3D Virtual Reality Performance Metrics as a Future Fatigue Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder, characterized by symptoms such as post-exertional malaise...

Some posts have been moved to: A thread of no importance. Post something completely inconsequential.

What exactly are you basing T/A coding for valine on? Edit: You previously said the opposite for A and G. Why has that changed?

Yes, it looks comparable. The Post-exertional malaise topic (capitalized above) has a large correlation, but who knows what terms this encompasses. The specific term "post exertional malaise" is lower, but still high. Honestly, the idea about the correlation of ME/CFS searches with British...