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The researchers looked at expression of SHISA6 in a different cohort: The plot is very blurry, so it's hard to make out what that number is, but I assume it's a p-value, and I think the exponent is -10. 8 out of 9 of their GWAS candidate genes seem to show significant differential...

Maybe a connection with IBS in the following study which found an association of a SNP near SHISA6 with nausea after general anesthesia: Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting (2023, Cancers)

Also see thread: Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study, 2024, Huang et al

A locus overlapping SHISA6 was nearly genome-wide significant in DecodeME (thread).

Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study Background Irritable bowel syndrome (IBS) significantly impacts individuals due to its prevalence and negative effect on quality of life. Current...

It looks like unfortunately the magic expired and the custom track is no longer at that link. Fortunately, there are ways to make it stick around permanently, described here and here. One way is to register, then you can create a named session which won't expire, and share the link. Another way...

Yes, but this region on chromosome 6 has a large number of genes densely packed together, so I think it's plausible that a variant can affect multiple genes here. A variant could very well be directly affecting one gene, which in turn affects another gene, and both would show up as associated...

I posted on the CA10 thread about a website called the Genotype-Phenotype Map, where you can upload summary stats, and it tests for colocalization (testing if traits share a causal variant) of the uploaded trait with thousands of other GWAS traits and millions of molecular traits. I thought...

The locus near SHISA6 wasn't quite genome-wide significant, but it was close at p=8.26e-08. From GeneCards: Here is a plot of this locus (LocusZoom link): Edit: The lead variant at this locus is: 17:11,325,637:G:C / rs1546559

I posted on the CA10 thread about a website called the Genotype-Phenotype Map, where you can upload summary stats, and it tests for colocalization (testing if traits share a causal variant) of the uploaded trait with thousands of other GWAS traits and millions of molecular traits. I thought...

I posted on the CA10 thread about a website called the Genotype-Phenotype Map, where you can upload summary stats, and it tests for colocalization (testing if traits share a causal variant) of the uploaded trait with thousands of other GWAS traits and millions of molecular traits. I thought...

I posted on the CA10 thread about a website called Open GWAS / Genotype-Phenotype Map, where you can upload summary stats, and it tests for colocalization (testing if traits share a causal variant) of the uploaded trait with thousands of other GWAS traits and millions of molecular traits. I...

Way out of left field now... Analysis of genomic selection characteristics of local cattle breeds in Gansu (2025, BMC Genomics) This study analyzed genomes of various cattle breeds in China to identify which genes may have played important roles in natural or artificial selection of cattle to...

A review of ME/CFS studies: Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity, 2026, Woo et al (thread link)

Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a major clinical challenge as a complex multisystemic disorder with no well-established...

I downloaded the GWAS summary stats for that cingulate gyrus metric to see if there's evidence of colocalization. Visually, at first it looks promising: The most significant variants in both traits are in the far left portion of the locus. Zooming in on that most significant little portion...

Here are traits associated with this variant if relaxing the threshold to p<1e-4. There are a few other brain related metrics. Curiously, row 13 is the trait "biological sex". It's from an interesting study: Genetic analyses identify widespread sex-differential participation bias (2021...

The above study said: CA10 (and CA8, CA11) is unlike most members of the CA gene family, in that it does not catalyze the reaction of CO2 to HCO3-. It is called carbonic anhydrase-related protein 10, in contrast to, for example, carbonic anhydrase 9. Carbonic anhydrase-related protein CA10 is...

Just seeing what's in this paper about CA10. The most significant SNP associated with neck or shoulder pain in this UK BioBank cohort was at the CA10 locus. This SNP did not replicate in Finland's FinnGen biobank (p=.20), though they say the phenotype they used in FinnGen is "shoulder issues"...

Predicting Potential Treatment Targets for Fatigue in Chronic Fatigue Syndrome Using Thalamic Seeding Background Chronic fatigue syndrome (CFS) is a neurological disorder. Functional connectivity (FC) abnormalities have been implicated in fatigue symptoms, but candidate cortical targets for...