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  1. Jonathan Edwards

    Comforting factors that influence the severity of fatigue and other somatic symptoms from the perspective of CFS, 2020, Overgaauw

    You are not trying hard enough, @dave30th. Think of an Italian ice cream store. Sort the soothing influences into cone size, chocolatey and other toffeeish ones, pink ones, green ones and white ones. Then build a hierarchy on your cone and coloured scoops and eat it before it all drips on the...
  2. Jonathan Edwards

    (ME) outbreaks can be modelled as an infectious disease: a mathematical reconsideration of the Royal Free Epidemic of 1955, 2020, Waters et al

    I suspect that everybody agrees that it is highly likely that all these outbreaks were mini-epidemics of infection. The issue of suggestibility merely relates to certain patterns of symptoms picked out by Ramsay as indicating encephalitis which probably didn't. In an age when unknown infection...
  3. Jonathan Edwards

    (ME) outbreaks can be modelled as an infectious disease: a mathematical reconsideration of the Royal Free Epidemic of 1955, 2020, Waters et al

    I am afraid I think this paper tells us nothing useful. Nevertheless, all credit to the authors for getting something published and trying a fresh approach. The problems I see: 1. The fact that some thought-to-be-hysterical outbreaks do not fit an empirically derived formulator infectious...
  4. Jonathan Edwards

    Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS, 2020, Lipkin et al

    The main message I get from this is that there were no differences between ME/CFSand controls on a straightforward comparison of levels of expression of VH genes (I have always been familiar with the term VH, rather than IGHV). The difference they claim appears with a mathematical transformation...
  5. Jonathan Edwards

    Coronavirus - worldwide spread and control

    I think it very unlikely that the method of attributing deaths will make a substantial difference. The proportion of people who die within a three month period (in general) is very small - maybe 0.3%. So just conceivably the figures might be 30% overestimates but that would not account for the...
  6. Jonathan Edwards

    Coronavirus - worldwide spread and control

    Something bothers me about the continuing figures for the UK, an indeed for all countries. It seems reasonably certain that overall death rate from symptomatic Covid-19 infection is some where around 1%, or would be if all age groups were affected equally. I am being very approximate here. Yet...
  7. Jonathan Edwards

    When it looks like a horse

    But do we know what really happened? I am well aware that many of my colleagues are hamfisted but it seems to me they acted pretty reasonably. They diagnosed a CSF leak - since that is th reason for post-lumbar puncture headache. I do not know the evidence on blood patches but I suspect it is...
  8. Jonathan Edwards

    When it looks like a horse

    The trouble is we do not know what it is. Things are complicated in this sort of area. At least the person talking is improving but I don't think we can know why.
  9. Jonathan Edwards

    Journal of Nuclear Medicine: 18F-FDG PET/MRI of patients with chronic pain alters management (2020)

    No, just glucose uptake. I am doubtful that assessing glucose uptake is a good way to diagnose occipital neuralgia, fibrosed plantaris (if such a thing exists) or CSF leaks. We have had ways of measuring local inflammation for decades and this is a rather expensive alternative that I suspect...
  10. Jonathan Edwards

    United Kingdom: Scotland NHS Lothian ME/CFS clinic

    Pacing is used as a user-friendly term for patients but the emphasis is on supported, controlled activity management to help the patients get fitter and stronger. So the dishonesty is in black and white: Pacing is used as a user-conning term for patients ... This is the sort of stuff I could...
  11. Jonathan Edwards

    United Kingdom: Scotland NHS Lothian ME/CFS clinic

    Or transcribed the contents of a helpful email from a 'colleague' - which was rather what I was trying to imply.
  12. Jonathan Edwards

    United Kingdom: Scotland NHS Lothian ME/CFS clinic

    I find it very hard to believe that that submission was not written at least in part by one of the PACE authors. It repeats all the false arguments run defence.
  13. Jonathan Edwards

    United Kingdom: Scotland NHS Lothian ME/CFS clinic

    I remember being told by a prominent psychologist that criticism of PACE was irrelevant because psychologists do not use that technique any more - it is all tailored to the individual. I think it is perfectly right that treatment should be tailored to the individual. I always tried to do that...
  14. Jonathan Edwards

    Making and managing medical anomalies: Exploring the classification of ‘medically unexplained symptoms’, 2020, Rasmussen

    Ye cannae shove yer Granny off a Bus And ye cannae shove a metaphor for MUS Tis a mere abstraction A mental malefaction Nay, ye cannae shove a metaphor for MUS.
  15. Jonathan Edwards

    Making and managing medical anomalies: Exploring the classification of ‘medically unexplained symptoms’, 2020, Rasmussen

    It seems that Erik Rasmussen is a young social worker with a pony tail and shaggy beard who has perhaps realised that he has wandered into the doo-doo of liaison psychiatry and pass-the-buckology. Maybe this is his attempt at saying as politely as he can, i.e. not to get himself sacked next...
  16. Jonathan Edwards

    Coronavirus - worldwide spread and control

    And a vastly greater number of people with ordinary serious illnesses not being treated.
  17. Jonathan Edwards

    NICE Statement about graded exercise therapy in the context of COVID-19

    Gerade was head of Royal College of General Practitioners rather than Physicians. Worth remembering that Royal Society of Medicine is a club, not an academic body like the colleges.
  18. Jonathan Edwards

    Coronavirus - worldwide spread and control

    It is perfectly possible, if like some countries have done, you build the hospitals afresh. The absurd thing about the UK is that we built the Nightingale hospitals and then did not use them. This is a measure of just how scatterbrained the approach has been.
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