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Its focus is on long Covid.

Diagnostics for brain infections are woefully bad, startling so. When I think of uncontested chronic brain infections, truly chronic, I think of the likes of neurospyphilis, and I believe tests even for that remain indirect. If you want direct testing for many of these neuro-infections...

Fukuda?? Why would any ME/CFS literate researcher use Fukuda?

"subjective phenomena"?? Which brain fog symptoms would be excluded from "symptoms"? And why is she acting like the use of brain fog is new, and is primarily a patient thing? In my experience I see doctors using it more, far more than I. I think it's dated and uninformed and demeaning - and...

Nevertheless, I suspect this may be what happens, only I doubt it's likely to be a single test, not in the near term at least. It is more likely to be a combination of tests, an algorithm e.g. low vasopressin, low NK cell function, low VEGF etc). Say three out of four or five values. Why a...

In many regards, dogs are the canaries in the coal mine. If I recall correctly, the way Canada estimated the spread of Lyme was through tracking canine (wolves?) migration routes. We all project. I am convinced my rescue dog is labouring with tick-borne diseases. Unfortunately, any diagnostic...

This is where sickness behavior might finally yield some relevance. I can think of a number of contested human diseases that could plug and play here, potentially.

Curious to see Baraniuk publishing with Marshall-Gradisnik.

I have POTS and my BP can range quite a bit. Perhaps a more appropriate phrasing would be "In so-called postural orthostatic tachycardia the BP can be normal." I was diagnosed with OI a couple of years before POTS.

Get in line.

As long as a disease like ME/CFS remains contested, a diagnostic test can benefit patients. With disability and health insurance claims challenged far too frequently, and a skeptical public that can include family and friends, a diagnostic that can rise above those challenges would be welcome...

Very cool. Can you tell that I - although a fan of IGeneX - have never used any of its products? I like that they test for more than one strain, and for several species. As I recall, the NIH used to refuse to test for anything other than Bb sensu stricto. This made no sense to me - how do you...

I had the vague feeling immunoblot and western blot were pretty much the same thing, or at least employed the same process. I could be wrong. IGeneX, as usual, simply allows for more bands than conventional testing, including OspC and OspA. Unfortunately, dx will remain questionable despite...

https://igenex.com/press-release/lyme-immunoblot-receives-fda-clearance/

Viruses are pretty much everywhere, of course. Still, this nematode study is curious, if only for potential import. https://www.lstmed.ac.uk/news-events/news/newly-discovered-viruses-in-parasitic-nematodes-could-change-our-understanding-of

Personally, I'd like to see something that reflects the individual nature the disease can manifest itself in patients. (awkward wording, sorry) Something that captures that ME/CFS is characterized by a symptom complex or amalgam. I'd emphasize those symptoms can vary by individual in frequency...

Add bartonella (have a cat?) and babesiosis (take walks in parks or woods?) to that list, at least potentially.

Diseases, and particularly infections, that attack red blood cells are, I think, more common than most people appreciate. Since impaired skeletal muscle function is at play in many such cases, perhaps there is a subset of pwME that may be impacted.

Thanks for the explanation. I thought it might be something along those lines when I read the discussion. Still seemed needlessly psychological when trying to infer organic brain problems. It warrants a slower and more deliberate read-through, if only for the historical Wallit ties.

This "cognitive conflict" reference is unsettling.