Search results

If you are asking the same question in multiple ways (i.e. multiple outcomes essentially measuring the same thing) then you should worry if they don't provide the same answer (high correlation between measures). If they don't then you have an issue with something in your experiment which needs...

What methods are they using to deal with uncertainty from a mathematical perspective? [Adding additional comments] The methods are of course critical in that any underlying assumptions of (since uncertaintly is mentioned) known distributions, normal data or error, or linearity of measures and...

If a trial is designed with bad primary outcomes then then that should lead to basic questions being asked about the competence of those running the trial. If they can't select sufficiently good primary outcomes then are the capable of running other aspect of the trial.? Hence I would say if a...

yes

Yes I was also arguing that other measures from such a trial may be valid. I also like the idea of looking for correlations between multiple measures if they are essentially trying to measure the same thing then all the measures should correlate. In some instances there may be errors but if the...

I was careful in stating the intersection of Oxford and the other criteria as well as this is what they measured and yes they did strange things with the criteria. But I don't believe they selected a set of patients which their favored interventions would work with my intuition looking at the...

The way I would think about it is there are all these different ways that people interact each with different chances of spreading the virus and where different amounts of the population take part. The spread will then be a function of the numbers of infected people doing each of the activities...

I'm not sure why pain outcomes are valid for an unblinded surgery trial. An important question is how you would judge reliability which I can only see being done by correlating with other non-subjective measures (or less subjective measures). I suspect there is also an effect size issue - where...

The question is not about self reports but about biases that are introduced due to self reports and whether they are mitigated by having a properly controlled trial. In the case of something like PACE where the intervention is designed to change how people think about an illness then the...

I think there is a basic question around whether data quality should exclude trials. This can take multiple forms such as the measures are too subject to biases (such as subjective outcomes with an open label trial) they could be because the measurement systems are simply not reliable etc...

Within each trial where data is included how much investigation is done into the trial and exactly what was measured. For example if they were to use the 6min walking test for PACE would they do enough work to find that the way it was administered was wrong as they didn't have a long enough...

One of the things with school attendance is it doesn't represent performance or how well a student is doing. So they may be their physically but not concentrating vs more limited attendance where they are doing more learning. There can also be places in schools for children who aren't well to...

One of my issues is around whether any protocol could be sufficient to look at the current trials. I certainly think that any protocol that uses subjective outcomes as its end-points is not worth bothering with. This could be made worst if (as with the current protocol) they use the CFQ as a...

This paper is the one that talks about the immune response being there in uneffected people - I think because they are saying that there is some recognition of the spike proteins in some people from other infections. That is a different issue as to whether antibodies formed for SARS-CoV2 will...

I noticed this tweet from an MP (Concerning the government removing on-line voting and making MPs queue to vote) who suffers from POTS and thought it was worth flagging as she may be sympathetic

The thing with asymptomatic cases is probably more complex in that there may be people with mild symptoms who basically just ignore them and carry on as normal. They're not really asymptomatic but behave as if they were. I think as a society we have become quite conditioned to trying to carry on...

One of the things I have seen suggested is the need to provide support for people who are isolating. Currently I suspect many people would find it hard to stay at home and not go out for 14 days as they don't have that much food in the house and can't get delivery slots. I don't know if this...

@sTeamTraen has raised some stats issues with this paper

I think this may be an interesting set of tweets around the spread pattern into the US with references to a couple of paper. The point I think is that the outbreak in Washington state had two particular mutations and there seems to be a lack of evidence for versions recorded in Wuhan or even...

It does surprise me how little data there seems to be about things like where spread seems to be happening. It suggests that they are either not trying to analyse spread patterns or don't want to talk about it. To me this data should help with any form of tracing. Hospitals and care homes seem...