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I agree it intuitively seems more likely for it to impair function. I'm not sure if there's anything we can do with it, but the qualifying variants in the BTN2A1 gene in the ME/CFS group are listed here...

Do we have reason to think it is defective? As I said previously, I don't think rare missense mutations necessarily imply the protein is "defective". Maybe it is working too well.

I just did a quick search for county level elevation data for every county in the US, but had trouble finding a good source. If we do find it, it'd require merging counties into metro areas, as I did previously for county level ancestry data, if we want to correlate against search interest data...

But isn't the only clue we have that points to CRH that it may be depleted in the hypothalamus? If anything in those paragraphs is relevant, it must basically depend on CRH being globally affected.

Exercise-Based Rehabilitation in Severe COVID-19 Survivors with Long COVID: A Randomized Controlled Pilot Study Edson Fonseca Pinto, Nailton José Brandão Albuquerque Filho, Jéssica Costa Leite, Tatianne Moura Estrela Gusmão, Larissa Nayara de Souza, Roque Ribeiro da Silva Júnior , Maria Irany...

Vascular Inflammation in Neuropsychiatric Long COVID Lindsay S. McAlpine MD 1 b, Eran F. Shorer MD MSc 2, Jennifer Chiarella BS 1 b, Allison Nelson RN 1 b, Rebecca Veenhuis PhD 2, Alba Azola MD 2, Alfred Lee MD 1, Richard Pierce MD 1, Shelli Farhadian 1 b, Leah H. Rubin PhD 2, Serena S. Spudich...

Caption for the above figure:

Can gdT cells "teach" abT cells or B cells? Like through recruiting them to come see the antigen they detect, leading to clones of the other cells?

Following on from the above about CA10 and MCT1/lactate: in whatever way CA10 can increase risk of ME/CFS, it's likely that the same mechanism would increase risk for chronic pain, since both conditions share a causal variant near CA10. So assuming that mechanism has something to do with...

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1 Web | DOI | PMC | PDF | FEBS Open Bio | Open Access CA10 (also known as CARP X) can increase the rate at which the protein MCT1 transports lactate across the cell membrane. Somewhat interesting...

Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study Background A subset of individuals experience prolonged neurological and psychiatric symptoms following SARS-CoV-2 infection, a condition referred to as long...

I'm not sure how many of the participants had ME/CFS, but a few of the free text responses for negative effects in the supplementary file talk about crashes or something like a crash:

Transdiagnostic cognitive behavioral therapy for severe and persistent fatigue – a feasibility study in primary care Frank Svärdman, Conrad Samuelsson, Ludwig Franke Föyen, Anna Oremark, Anna Högfeldt, Jacob Andersson Emad, Douglas Sjöwall, Christian Rück, Erik Hedman-Lagerlöf, Hans Knoop, Elin...

There seem to be some mistakes with the percentages in that table. For "Headache", 73/141 = 51.8%, not 55.8%. For "Poor memory", 84/141 = 59.6%, not 9.6%. For "Visuo-spatial/balance/coordination, 92/141 = 65.2%, not 62.2%.

ME Research UK: "Could reaction times to 3D virtual reality tasks act as a biomarker for fatigue in ME/CFS?" 'Although this was a relatively small study, the results showed that when compared with those of healthy controls, reaction times of those with ME/CFS were significantly slower. It was...

Correspondence about this. I can't access the letter from Wyller et al, but the reply to it gives a good idea of what was said. Methodological considerations for interpreting a scoping review of pediatric long COVID biomarkers Joel Pradeepkumar Selvakumar, Vegard Bruun Bratholm Wyller Web | DOI...

Biomarkers of long COVID in children and young adults: a scoping review Bettina Camara, Danilo Buonsenso Abstract Following the SARS-CoV-2 pandemic, a significant percentage of people are now experiencing long-term symptoms, despite a continuing lack of concrete documentation of physiological...

This is on patients who have long COVID and ME/CFS. ME/CFS diagnosis seems to be based on the DePaul symptom questionnaire. I'm not sure if they also had to fulfill other criteria. Strikingly large difference between groups for anti-calcium sensing receptor (CaSR) antibodies: No...

Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation Stephanie L. Grach, Jaime Seltzer, Michael R. Mueller, Chris A. Aakre, Lasonya T. Natividad, Donna K. Lawson, Ravindra Ganesh, Ryan T. Hurt PURPOSE Myalgic...

Changes from preprint abstract. New additions in bold, removed parts are struck out.