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Hopefully others provide some ideas, as I'm a beginner in neuroscience, so I don't have a good idea of what areas are most promising in terms of symptoms. If I was forced to choose an area to study CA10 in, I'd probably look at the cerebellum. It looks to be most highly expressed there, and...

494 IgG-mediated mast cell dysregulation drives chronic pain in post-acute sequelae of SARS-CoV-2 (PASC) Limerick, Gerard; Sanchez, Karla; Dong, Xinzhong Web | DOI | PDF | Journal of Clinical and Translational Science | Abstract

The GWAS studies found that a mutation near the CA10 gene is associated with risk of these conditions, but that doesn't itself provide much detail on what the mutation does, such as whether it upregulates or downregulates CA10 in the brain. The mutation that increases risk of ME/CFS seems to...

I've been reading about CA10, and I thought it would be useful to compile what I was reading into a mini-review, for my own and others' future reference. This isn't meant to include interpretation of how different CA10 findings may fit together, but rather it's basically a compilation of almost...

SolveME sent a newsletter and has a page about providing funds for a couple projects, including SequenceME. I posted on the Solve thread. This is from the email: Is this new funding we hadn't known about yet?

New Catalyst Award Funding From Solve M.E. Advances Innovative ME/CFS and Long Covid Studies Toward Treatments "May 12, 2026 In recognition of World ME Day, Solve M.E. announced today new funding for two award-winning research studies aimed at accelerating progress toward diagnostics and...

O15 Is there more to understand about circadian rhythm sleep wake disorders (CRSWDs) in young adults with autistic spectrum conditions (ASC) referred to myalgic encephalopathy/Chronic fatigue syndrome (ME/CFS) services? A case report Catchpool, Nicola; Hill, Elizabeth Web | DOI | PDF | BMJ Open...

A couple new relevant threads: Webinar: SequenceME & Long Covid Phase 2 funding, May 26, 2026 02:30 PM UK Blog: DNA sequencing study to help pinpoint biology of ME gets £4.7m

Note that the discussion about the above SequenceME news can be found here: SequenceME genetic study - from Oxford Nanopore Technologies, the University of Edinburgh and Action for ME

Ah, I misunderstood the abstract, and thought they were saying that the SSTAE group improved compared to baseline, even though the control group improved just as much. I actually looked at the paper now, and see there was a significant difference compared to controls on the secondary endpoint of...

Did it? The abstract makes it seem like a null finding, where exercise was not useful compared to the patients who didn't do exercise. Yet they frame it like exercise was beneficial.

Effects of Sub–Symptom Threshold Aerobic Exercise on Persistent Postconcussion Symptom Burden and Exercise Intolerance: A Randomized Controlled Trial Importance Persistent postconcussion symptoms (PCS) following mild traumatic brain injury (mTBI) are common and are often associated with...

Got it. Thanks, sound good.

Thanks. Maybe I'm looking at the wrong data, or it's been updated? In the Table 1 spreadsheet file from the paper supplementary files, only some of the participants have an SF36 score at week 52. If I subtract Week -12 from Week 40 (so still 12 months, but it's the latest point where everyone...

I think because of the correlation with improvement. which provides a bit more evidence that it's the antibody depleting mechanism of dara that is relevant to improvement. Before, we knew that the more NK cells someone had, the more they improved, but we couldn't be sure that the people with...

Dr. Kaufman talks about prescribing antivirals to his patients in his podcast. Earlier he talks about measuring antibody titers to viruses, so prescribing antivirals might be limited to those patients with high levels, though I haven't listened to the whole thing in detail. Edit: I think his...

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections Web | DOI | PMC | PDF | Nature Communications | Open Access This study found an association between an intronic CA10 variant and self-reported bacterial meningitis. What was...

Trends in physical fitness before and after the COVID-19 pandemic in Austrian children Drenowatz, Clemens; Greier, Klaus; Hinterkörner, Franz Background It has been well-documented that the COVID-19 pandemic and implemented policies disrupted physical activity and negatively affected physical...

Short letter in a Canadian journal. I think it's in response to: Exercise and pharmacologic management of fibromyalgia (2026, Canadian Family Physician) Exercise May Cause Harm in a Subset of Fibromyalgia Patients Snippets: Web | Canadian Family Physician | Letter | 2026

Effect of a third COVID-19 vaccine dose on the incidence of Long COVID among adults who completed a primary vaccine series: a target trial emulation in a community-based cohort Background Evidence on whether a third COVID-19 vaccine dose lowers long COVID risk is mixed. We estimated the...