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  1. J

    Lilly says Alzheimer's drug slows clinical decline in mid-stage trial

    https://www.reuters.com/article/us-elililly-alzheimers/lilly-says-alzheimers-drug-slows-clinical-decline-in-mid-stage-trial-idUSKBN29G161 https://www.bloomberg.com/news/articles/2021-01-11/lilly-surges-as-experimental-alzheimer-s-drug-shows-promise
  2. J

    The possibility of autoimmunity or auto-reactivity in ME/CFS

    What type of T cells? By activation you mean they are pumping out cytokines? If so, wouldn’t this have shown up on tests? If there is abnormal T cell activation, wouldn’t cyclophosphamide or Campath treat this? Also, what exactly is a hidden compartment? Thanks.
  3. J

    Open Medicine Foundation (OMF)

    This represents your opinion— it was not the conclusion of the authors of the study.
  4. J

    Open Medicine Foundation (OMF)

    There are a lot of auto-immune diseases that don’t respond to rituximab like type 1 diabetes and lupus. Fluge & Mella believe there is an auto-immune component to ME/CFS—from the cyclophosphamide paper
  5. J

    Open Medicine Foundation (OMF)

    They probably have a biomarker now— my guess! Sounds optimistic. Maybe they figured out the Abilify tolerance thing as well.
  6. J

    Open Medicine Foundation (OMF)

    Abilify can alter sleep but it sounds like he naturally only sleeps 2 hours per day.
  7. J

    Open Medicine Foundation (OMF)

    Good article. Abilify I believe. Surprised to hear that Whitney only sleeps 2 hours a day. Seems really bad.
  8. J

    The use of the labels ME, CFS, ME/CFS

    Agree with @Bill—probably not a good idea to subdivide patients with the MECFS syndrome into subgroups based on which symptom is the most prominent or disabling— this is what Guido was trying to do (I think).
  9. J

    Aripiprazole - Abilify

    Correct. I tried to make this same point on a different thread. Plus they are too busy plus there is no incentive for them to conduct trials/publish results.
  10. J

    Research news from Bhupesh Prusty

    Maybe Viking HLA genes are different??
  11. J

    Aripiprazole - Abilify

    https://med.stanford.edu/content/dam/sm/dbds/documents/data-studio/abstract.20201118.pdf Retrospective data analysis of Abilify plus plans for a randomized clinical trial. 74% of patients reported symptom improvement. @Jonathan Edwards —your critical thoughts?
  12. J

    Aripiprazole - Abilify

    They also need to look at the tachyphlaxis (poop out) mechanism and how to overcome it.
  13. J

    Research news from Bhupesh Prusty

    skeptical of this. And this
  14. J

    Largest GWAS (N=1,126,563) of Alzheimer’s Disease Implicates Microglia and Immune Cells. (2020) /Preprint medrxiv.org/content/10.110…

  15. J

    Largest GWAS (N=1,126,563) of Alzheimer’s Disease Implicates Microglia and Immune Cells. (2020) /Preprint medrxiv.org/content/10.110…

  16. J

    Ed Yong webinar Monday, 7 December 2020

  17. J

    Ed Yong webinar Monday, 7 December 2020

  18. J

    Use of sildenafil (viagra) to alter fatigue, functional status and impaired cerebral blood flow in ... CFS, 2020, Friedman (Pfizer)

    Looks promising— not sure why Pfizer didn’t follow up.
  19. J

    NIAID will host “Workshop on Post-Acute Sequelae of COVID-19” on Dec 3-4 2020

    Comments on the above {crappy} NYT article are open now—please make comments about MECFS—thanks.
  20. J

    Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis..., 2020, Nourbakhsh et al

    Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext
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