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  1. J

    Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans. Thapaliya et al. 2020

    Does this mean we need a med that crosses the blood brain barrier to treat our pathological brains? Or will fixing the non-brain issues subsequently fix the brain? Nimodipine (calcium channel blocker) crosses BBB Cyclophosphamide crosses BBB
  2. J

    Short summary of meds i tried by now

    @Badpack What symptoms did phenytoin help with? Did you stop taking it? Thanks
  3. J

    Genetic Risk Factors of ME/CFS: A Critical Review. Joshua J Dibble, Simon J McGrath, Chris P Ponting. 2020

    Congrats Simon!
  4. J

    Biomedical research findings in ME/CFS that were replicated by multiple groups - discussion thread

    Low serum folate—maybe/maybe not. I’m really surprised that there was no follow up on the 1993 study until 2019. Did I miss some studies? https://n.neurology.org/content/43/12/2645 ~3 ug/l https://www.mdpi.com/2075-4418/9/2/41 Nacul didn’t statistically compare mild/moderate to control...
  5. J

    Digital Behavior Change Interventions for Younger Children With Chronic Health Conditions: Systematic Review, 2020, Crawley, Loades et al

    Yes, absolutely. There are 10 authors on this "super important" study. If they each spent 10 weeks total on this at an average of $2000 weekly salary plus benefits, that's $200,000 that could have been spent on something useful. (sorry for $, I know this is the U.K.).
  6. J

    Biomedical research findings in ME/CFS that were replicated by multiple groups - discussion thread

    Very low ESR https://ashpublications.org/blood/article/132/Supplement 1/4874/262252/Erythrocyte-Deformability-As-a-Potential-Biomarker https://www.consultant360.com/content/chronic-fatigue-syndrome-update-diagnosis-primary-care
  7. J

    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption. Tolle, Scheibenbogen et al. 2020

    You mean they would be very vulnerable to contracting/dying from an infection with that much IgG depletion?
  8. J

    Evidence for a genetic component in ME/CFS - discussion thread

    Ponting threads https://www.s4me.info/threads/significant-association-of-dna-variants-with-self-reported-me-cfs-chris-ponting-blog.5520/ https://www.s4me.info/threads/analysis-of-data-from-500k-individuals-in-uk-biobank-shows-an-inherited-component-to-me-cfs-ponting-blog.4529/...
  9. J

    Robuvit - oak wood extract supplement

    No idea, actually. I just wanted to see it had a similar structure pycnogenol, but it is different
  10. J

    Robuvit - oak wood extract supplement

    Looks like a bigger molecule than pycnogenol https://www.sciencedirect.com/science/article/abs/pii/S0367326X10001413 https://www.robuvit.com/science https://www.robuvit.com/fileadmin/robuvit/robuvit_brochure_EN_161_WEB.pdf Oak>pine
  11. J

    Richard Horton on Covid-19

    https://www.washingtonpost.com/world/europe/lancet-richard-horton-trump-vaccines/2020/07/29/1209b610-d048-11ea-826b-cc394d824e35_story.html?utm_medium=social&utm_campaign=wp_main&utm_source=twitter Long interview of Richard Horton Moderator note: We are aware that the linked article includes...
  12. J

    Michael VanElzakker

    Seems like feeling good or feeling better would be a reasonable goal for any treatment.
  13. J

    Chronic fatigue syndrome may hold keys to understanding post-Covid syndrome: David Tuller and Steven Lubet July 21, 2020

    Do you have evidence to support this statement? By “they” do you mean all the people involved in the development of these several diagnostic criteria? Unfortunately this sounds like a non-evidence based conspiracy theory.
  14. J

    Coronavirus - worldwide spread and control

    Surprise!
  15. J

    Chronic fatigue syndrome may hold keys to understanding post-Covid syndrome: David Tuller and Steven Lubet July 21, 2020

    All except ICC require 6 months
  16. J

    Chronic fatigue syndrome may hold keys to understanding post-Covid syndrome: David Tuller and Steven Lubet July 21, 2020

    This thread is starting to give me the heebie-jeebies. 1) There is no definitive biomarker for ME/CFS 2) In light of no definitive biomarker, the disease or the syndrome called ME/CFS is diagnosed based on symptoms 3) If you have the symptoms for 6 months then you have ME/CFS (by definition) 4)...
  17. J

    Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS, 2020, Lipkin et al

    If the energy Gods allow, it would be great to see a write up on this from @Simon M Also would really welcome commentary from the B-cell slayer https://science.sciencemag.org/content/318/5854/1232.summary @Jonathan Edwards
  18. J

    Chronic fatigue syndrome may hold keys to understanding post-Covid syndrome: David Tuller and Steven Lubet July 21, 2020

    Yes, this was my point. If you meet the various diagnostic criteria, at 5 months 30 days you still have "post-covid". By definition, if you meet the criteria at 6 months you have ME/CFS. If experts want to change this threshold to 8 months or to 4 months, I wouldn't object. If "experts" want...
  19. J

    Chronic fatigue syndrome may hold keys to understanding post-Covid syndrome: David Tuller and Steven Lubet July 21, 2020

    Although I applaud the general goal of this article, I believe it has some problems/inaccuracies. 1) This authors beat around the bush about the "connection" between post-covid illness and ME/CFS It would have been better for the authors to state explicitly that after 6 months, people with...
  20. J

    Elena Delle Donne—An open letter about my health

    Well if she has had “this” for 10 years and still won 2 MVPs and been a 6X All-Star, that is pretty remarkable. https://en.m.wikipedia.org/wiki/Elena_Delle_Donne
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